Increased regression and decreased incidence of human papillomavirus- related cervical lesions among HIV-infected women on HAART

David H. Adler, Lisa Kakinami, Tebogo Modisenyane, Nkeko Tshabangu, Lerato Mohapi, Guy De Bruyn, Neil A. Martinson, Tanvier Omar

Research output: Contribution to journalArticle

Abstract

Objective: To determine the impact of HAART on incidence, regression, and progression of cytopathological abnormalities in HIV-infected women. Design: Prospective cohort. Methods: HIV-infected women (N=1123) from Soweto, South Africa underwent serial cervical smears that were analyzed and reported using the Bethesda System. The results of HAART and non-HAART users were compared using two statistical approaches: a survival analysis assessing risk of incident smear abnormality among women with baseline normal smear results; and analysis with marginal models assessing for an association between HAART use and likelihood of regression/progression in consecutive smears. Results: After multivariate survival analysis, women using HAART with a normal baseline smear were 38% less likely to have an incident smear abnormality during follow-up than nonusers [confidence interval (CI) 0.42-0.91; P=0.01]. Multivariate marginal models analysis identified a significantly increased likelihood (odds ratio 2.61; CI 1.75-3.89; P

Original languageEnglish (US)
Pages (from-to)1645-1652
Number of pages8
JournalAIDS
Volume26
Issue number13
DOIs
StatePublished - Aug 24 2012

Keywords

  • cervical cancer
  • disease progression
  • disease regression
  • HAART
  • Papanicolaou smear

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Adler, D. H., Kakinami, L., Modisenyane, T., Tshabangu, N., Mohapi, L., De Bruyn, G., Martinson, N. A., & Omar, T. (2012). Increased regression and decreased incidence of human papillomavirus- related cervical lesions among HIV-infected women on HAART. AIDS, 26(13), 1645-1652. https://doi.org/10.1097/QAD.0b013e32835536a3