TY - GEN
T1 - Increased Randomness of Functional Network Connectivity in Nicotine and Alcohol Consumers
AU - Vergara, Victor M.
AU - Hutchison, Kent
AU - Calhoun, Vince D.
N1 - Funding Information:
*This work was supported by the NIH grant numbers 2R01EB006841, 2R01EB005846, P20GM103472, and R01EB020407 as well as NSF grant 1539067 to VC.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/10/26
Y1 - 2018/10/26
N2 - Alcohol and nicotine are substances that alter the functional connectivity of the brain. These changes have been observed after pinpointing particular brain areas as well as studying the overall brain wiring structure. One property of this wiring structure is the level of randomness. Evidence strongly agrees that brain connectivity is not random, but that chemical substances can affect the connectivity structure. This work aims at studying changes in resting state functional connectivity randomness in relation to the consumption of nicotine and alcohol. Results suggest that randomness in whole brain connectivity is not affected by used substance. However, connectivity among particular brain areas does show changed randomness linked to substance use. Abnormal randomness was found between salience and default mode functional domains. This dysfunction is in line with some postulates of the network model of addiction. The study provides new information on the effects of substance use on the brain.
AB - Alcohol and nicotine are substances that alter the functional connectivity of the brain. These changes have been observed after pinpointing particular brain areas as well as studying the overall brain wiring structure. One property of this wiring structure is the level of randomness. Evidence strongly agrees that brain connectivity is not random, but that chemical substances can affect the connectivity structure. This work aims at studying changes in resting state functional connectivity randomness in relation to the consumption of nicotine and alcohol. Results suggest that randomness in whole brain connectivity is not affected by used substance. However, connectivity among particular brain areas does show changed randomness linked to substance use. Abnormal randomness was found between salience and default mode functional domains. This dysfunction is in line with some postulates of the network model of addiction. The study provides new information on the effects of substance use on the brain.
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U2 - 10.1109/EMBC.2018.8512392
DO - 10.1109/EMBC.2018.8512392
M3 - Conference contribution
C2 - 30440562
AN - SCOPUS:85056663569
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1011
EP - 1014
BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Y2 - 18 July 2018 through 21 July 2018
ER -