Increased QT dispersion in sickle cell disease: Effect of pulmonary hypertension

Ferit Akgül, Ergün Seyfeli, Ismet Melek, Taşkin Duman, Tunzale Seydaliyeva, Edip Gali, Fatih Yalçin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. Methods: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 ± 8.0 years) steady-state SCD patients and 25 (mean age 19.6 ± 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett's formula was used to obtain a rate-corrected value of the QT interval (QTc). Results: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCD patients compared to the control subjects (p <0.0001, p <0.05, p <0.0001, respectively). Among SCD patients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p <0.0001). However, minimum QTc showed no significant differences between the two patient groups. Conclusion: QTc dispersion is significantly increased in SCD patients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalActa Haematologica
Volume118
Issue number1
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Pulmonary hypertension
  • QT dispersion
  • Sickle cell disease
  • Ventricular repolarization

ASJC Scopus subject areas

  • Hematology

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