TY - JOUR
T1 - Increased Prevalence of Abnormal Glucose Tolerance among Obese Siblings of Children with Type 2 Diabetes
AU - Magge, Sheela N.
AU - Stettler, Nicolas
AU - Jawad, Abbas F.
AU - Levitt Katz, Lorraine E.
N1 - Funding Information:
Supported by Juvenile Diabetes Research Foundation–Lawson Wilkins Pediatric Endocrine Society (LWPES) Pediatric Endocrinology Fellowship Training Grant 13-2002-454, a Children's Hospital of Philadelphia General Clinical Research Center Junior Clinical Investigators Award, an LWPES Clinical Scholars Grant, National Institutes of Health (NIH) Career Development Award K12 DK63682, and NIH Grants 5-MO1-RR-000240 and UL1RR024134 from the National Center for Research Resources (NCRR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCRR or the NIH. There are no potential conflicts of interest, and the authors have nothing to disclose.
PY - 2009/4
Y1 - 2009/4
N2 - Objective: To test the hypothesis that overweight siblings of children with type 2 diabetes mellitus (T2DM) have a higher prevalence of abnormal glucose tolerance (AGT) compared with other overweight children. Study design: This was a cross-sectional study of overweight (body mass index [BMI] ≥ 95th percentile) subjects, age 8 to 17 years, with at least 1 sibling age ≥ 12 years. The primary outcome was AGT, as assessed by the oral glucose tolerance test (2-hour glucose ≥ 140 mg/dL). The secondary outcome was insulin resistance by homeostasis model assessment (HOMA). Results: The sibling (n = 20) and control (n = 42) groups were similar in terms of age, sex, racial distribution (largely African American), pubertal status, and BMI. The prevalence of AGT in the sibling group was 40.0% (n = 8), compared with 14.3% (n = 6) in controls (P = .048, Fisher exact test; unadjusted odds ratio = 4.0; 95% confidence interval = 1.2 to 13.5). Univariate analysis did not identify confounders for either outcome. There were no significant differences in HOMA or hemoglobin A1c between the 2 groups. Conclusions: Overweight siblings of children with T2DM had 4 times greater odds of having AGT compared with other overweight children. This group may represent a particularly high-risk population to target for screening and pediatric T2DM prevention.
AB - Objective: To test the hypothesis that overweight siblings of children with type 2 diabetes mellitus (T2DM) have a higher prevalence of abnormal glucose tolerance (AGT) compared with other overweight children. Study design: This was a cross-sectional study of overweight (body mass index [BMI] ≥ 95th percentile) subjects, age 8 to 17 years, with at least 1 sibling age ≥ 12 years. The primary outcome was AGT, as assessed by the oral glucose tolerance test (2-hour glucose ≥ 140 mg/dL). The secondary outcome was insulin resistance by homeostasis model assessment (HOMA). Results: The sibling (n = 20) and control (n = 42) groups were similar in terms of age, sex, racial distribution (largely African American), pubertal status, and BMI. The prevalence of AGT in the sibling group was 40.0% (n = 8), compared with 14.3% (n = 6) in controls (P = .048, Fisher exact test; unadjusted odds ratio = 4.0; 95% confidence interval = 1.2 to 13.5). Univariate analysis did not identify confounders for either outcome. There were no significant differences in HOMA or hemoglobin A1c between the 2 groups. Conclusions: Overweight siblings of children with T2DM had 4 times greater odds of having AGT compared with other overweight children. This group may represent a particularly high-risk population to target for screening and pediatric T2DM prevention.
UR - http://www.scopus.com/inward/record.url?scp=62649120910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62649120910&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2008.09.055
DO - 10.1016/j.jpeds.2008.09.055
M3 - Article
C2 - 19028390
AN - SCOPUS:62649120910
VL - 154
SP - 562-566.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 4
ER -