Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

Frauke von Versen-Höynck, Amelia M. Schaub, Yueh Yun Chi, Kuei Hsun Chiu, Jing Liu, Melissa Lingis, R. Stan Williams, Alice Rhoton-Vlasak, Wilmer W. Nichols, Raquel R. Fleischmann, Wendy Zhang, Virginia D. Winn, Mark S. Segal, Kirk P. Conrad, Valerie Baker

Research output: Contribution to journalArticle

Abstract

In vitro fertilization involving frozen embryo transfer and donor oocytes increases preeclampsia risk. These in vitro fertilization protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether in vitro fertilization pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Women with 0 (n=26), 1 (n=23), or >1 (n=22) CL were serially evaluated before, during, and after pregnancy. Because increasing arterial compliance is a major physiological adaptation in pregnancy, we assessed carotid-femoral pulse wave velocity and transit time. In a parallel prospective cohort study, obstetric outcomes for singleton livebirths achieved with autologous oocytes were compared between groups by CL number (n=683). The expected decline in carotid-femoral pulse wave velocity and rise in carotid-femoral transit time during the first trimester were attenuated in the 0-CL compared with combined single/multiple-CL cohorts, which were similar (group-time interaction: P=0.06 and 0.03, respectively). The blunted changes of carotid-femoral pulse wave velocity and carotid-femoral transit time from prepregnancy in the 0-CL cohort were most striking at 10 to 12 weeks of gestation ( P=0.01 and 0.006, respectively, versus 1 and >1 CL). Zero CL was predictive of preeclampsia (adjusted odds ratio, 2.73; 95% CI, 1.14-6.49) and preeclampsia with severe features (6.45; 95% CI, 1.94-25.09) compared with 1 CL. Programmed frozen embryo transfer cycles (0 CL) were associated with higher rates of preeclampsia (12.8% versus 3.9%; P=0.02) and preeclampsia with severe features (9.6% versus 0.8%; P=0.002) compared with modified natural frozen embryo transfer cycles (1 CL). In common in vitro fertilization protocols, absence of the CL perturbed the maternal circulation in early pregnancy and increased the incidence of preeclampsia.

Original languageEnglish (US)
Pages (from-to)640-649
Number of pages10
JournalHypertension (Dallas, Tex. : 1979)
Volume73
Issue number3
DOIs
StatePublished - Mar 1 2019
Externally publishedYes

Fingerprint

Corpus Luteum
Fertilization in Vitro
Pre-Eclampsia
Compliance
Thigh
Pulse Wave Analysis
Pregnancy
Embryo Transfer
Oocytes
Mothers
Physiological Adaptation
First Pregnancy Trimester
Obstetrics
Cohort Studies
Odds Ratio

Keywords

  • hormones
  • humans
  • pregnancy
  • pulse wave analysis
  • relaxin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum. / von Versen-Höynck, Frauke; Schaub, Amelia M.; Chi, Yueh Yun; Chiu, Kuei Hsun; Liu, Jing; Lingis, Melissa; Stan Williams, R.; Rhoton-Vlasak, Alice; Nichols, Wilmer W.; Fleischmann, Raquel R.; Zhang, Wendy; Winn, Virginia D.; Segal, Mark S.; Conrad, Kirk P.; Baker, Valerie.

In: Hypertension (Dallas, Tex. : 1979), Vol. 73, No. 3, 01.03.2019, p. 640-649.

Research output: Contribution to journalArticle

von Versen-Höynck, F, Schaub, AM, Chi, YY, Chiu, KH, Liu, J, Lingis, M, Stan Williams, R, Rhoton-Vlasak, A, Nichols, WW, Fleischmann, RR, Zhang, W, Winn, VD, Segal, MS, Conrad, KP & Baker, V 2019, 'Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum', Hypertension (Dallas, Tex. : 1979), vol. 73, no. 3, pp. 640-649. https://doi.org/10.1161/HYPERTENSIONAHA.118.12043
von Versen-Höynck, Frauke ; Schaub, Amelia M. ; Chi, Yueh Yun ; Chiu, Kuei Hsun ; Liu, Jing ; Lingis, Melissa ; Stan Williams, R. ; Rhoton-Vlasak, Alice ; Nichols, Wilmer W. ; Fleischmann, Raquel R. ; Zhang, Wendy ; Winn, Virginia D. ; Segal, Mark S. ; Conrad, Kirk P. ; Baker, Valerie. / Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum. In: Hypertension (Dallas, Tex. : 1979). 2019 ; Vol. 73, No. 3. pp. 640-649.
@article{23929aabedee40ff9e5bf02aa5caed7e,
title = "Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum",
abstract = "In vitro fertilization involving frozen embryo transfer and donor oocytes increases preeclampsia risk. These in vitro fertilization protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether in vitro fertilization pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Women with 0 (n=26), 1 (n=23), or >1 (n=22) CL were serially evaluated before, during, and after pregnancy. Because increasing arterial compliance is a major physiological adaptation in pregnancy, we assessed carotid-femoral pulse wave velocity and transit time. In a parallel prospective cohort study, obstetric outcomes for singleton livebirths achieved with autologous oocytes were compared between groups by CL number (n=683). The expected decline in carotid-femoral pulse wave velocity and rise in carotid-femoral transit time during the first trimester were attenuated in the 0-CL compared with combined single/multiple-CL cohorts, which were similar (group-time interaction: P=0.06 and 0.03, respectively). The blunted changes of carotid-femoral pulse wave velocity and carotid-femoral transit time from prepregnancy in the 0-CL cohort were most striking at 10 to 12 weeks of gestation ( P=0.01 and 0.006, respectively, versus 1 and >1 CL). Zero CL was predictive of preeclampsia (adjusted odds ratio, 2.73; 95{\%} CI, 1.14-6.49) and preeclampsia with severe features (6.45; 95{\%} CI, 1.94-25.09) compared with 1 CL. Programmed frozen embryo transfer cycles (0 CL) were associated with higher rates of preeclampsia (12.8{\%} versus 3.9{\%}; P=0.02) and preeclampsia with severe features (9.6{\%} versus 0.8{\%}; P=0.002) compared with modified natural frozen embryo transfer cycles (1 CL). In common in vitro fertilization protocols, absence of the CL perturbed the maternal circulation in early pregnancy and increased the incidence of preeclampsia.",
keywords = "hormones, humans, pregnancy, pulse wave analysis, relaxin",
author = "{von Versen-H{\"o}ynck}, Frauke and Schaub, {Amelia M.} and Chi, {Yueh Yun} and Chiu, {Kuei Hsun} and Jing Liu and Melissa Lingis and {Stan Williams}, R. and Alice Rhoton-Vlasak and Nichols, {Wilmer W.} and Fleischmann, {Raquel R.} and Wendy Zhang and Winn, {Virginia D.} and Segal, {Mark S.} and Conrad, {Kirk P.} and Valerie Baker",
year = "2019",
month = "3",
day = "1",
doi = "10.1161/HYPERTENSIONAHA.118.12043",
language = "English (US)",
volume = "73",
pages = "640--649",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

AU - von Versen-Höynck, Frauke

AU - Schaub, Amelia M.

AU - Chi, Yueh Yun

AU - Chiu, Kuei Hsun

AU - Liu, Jing

AU - Lingis, Melissa

AU - Stan Williams, R.

AU - Rhoton-Vlasak, Alice

AU - Nichols, Wilmer W.

AU - Fleischmann, Raquel R.

AU - Zhang, Wendy

AU - Winn, Virginia D.

AU - Segal, Mark S.

AU - Conrad, Kirk P.

AU - Baker, Valerie

PY - 2019/3/1

Y1 - 2019/3/1

N2 - In vitro fertilization involving frozen embryo transfer and donor oocytes increases preeclampsia risk. These in vitro fertilization protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether in vitro fertilization pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Women with 0 (n=26), 1 (n=23), or >1 (n=22) CL were serially evaluated before, during, and after pregnancy. Because increasing arterial compliance is a major physiological adaptation in pregnancy, we assessed carotid-femoral pulse wave velocity and transit time. In a parallel prospective cohort study, obstetric outcomes for singleton livebirths achieved with autologous oocytes were compared between groups by CL number (n=683). The expected decline in carotid-femoral pulse wave velocity and rise in carotid-femoral transit time during the first trimester were attenuated in the 0-CL compared with combined single/multiple-CL cohorts, which were similar (group-time interaction: P=0.06 and 0.03, respectively). The blunted changes of carotid-femoral pulse wave velocity and carotid-femoral transit time from prepregnancy in the 0-CL cohort were most striking at 10 to 12 weeks of gestation ( P=0.01 and 0.006, respectively, versus 1 and >1 CL). Zero CL was predictive of preeclampsia (adjusted odds ratio, 2.73; 95% CI, 1.14-6.49) and preeclampsia with severe features (6.45; 95% CI, 1.94-25.09) compared with 1 CL. Programmed frozen embryo transfer cycles (0 CL) were associated with higher rates of preeclampsia (12.8% versus 3.9%; P=0.02) and preeclampsia with severe features (9.6% versus 0.8%; P=0.002) compared with modified natural frozen embryo transfer cycles (1 CL). In common in vitro fertilization protocols, absence of the CL perturbed the maternal circulation in early pregnancy and increased the incidence of preeclampsia.

AB - In vitro fertilization involving frozen embryo transfer and donor oocytes increases preeclampsia risk. These in vitro fertilization protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether in vitro fertilization pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Women with 0 (n=26), 1 (n=23), or >1 (n=22) CL were serially evaluated before, during, and after pregnancy. Because increasing arterial compliance is a major physiological adaptation in pregnancy, we assessed carotid-femoral pulse wave velocity and transit time. In a parallel prospective cohort study, obstetric outcomes for singleton livebirths achieved with autologous oocytes were compared between groups by CL number (n=683). The expected decline in carotid-femoral pulse wave velocity and rise in carotid-femoral transit time during the first trimester were attenuated in the 0-CL compared with combined single/multiple-CL cohorts, which were similar (group-time interaction: P=0.06 and 0.03, respectively). The blunted changes of carotid-femoral pulse wave velocity and carotid-femoral transit time from prepregnancy in the 0-CL cohort were most striking at 10 to 12 weeks of gestation ( P=0.01 and 0.006, respectively, versus 1 and >1 CL). Zero CL was predictive of preeclampsia (adjusted odds ratio, 2.73; 95% CI, 1.14-6.49) and preeclampsia with severe features (6.45; 95% CI, 1.94-25.09) compared with 1 CL. Programmed frozen embryo transfer cycles (0 CL) were associated with higher rates of preeclampsia (12.8% versus 3.9%; P=0.02) and preeclampsia with severe features (9.6% versus 0.8%; P=0.002) compared with modified natural frozen embryo transfer cycles (1 CL). In common in vitro fertilization protocols, absence of the CL perturbed the maternal circulation in early pregnancy and increased the incidence of preeclampsia.

KW - hormones

KW - humans

KW - pregnancy

KW - pulse wave analysis

KW - relaxin

UR - http://www.scopus.com/inward/record.url?scp=85061488150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061488150&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.118.12043

DO - 10.1161/HYPERTENSIONAHA.118.12043

M3 - Article

VL - 73

SP - 640

EP - 649

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3

ER -