Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: A pilot study in patients with major depression

Christopher M. Marano, Pornima Phatak, Ugandhar Rao Vemulapalli, Amritpal Sasan, Maria R. Nalbandyan, Sailakshmi Ramanujam, Surjo Soekadar, Maria Demosthenous, William T. Regenold

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The therapeutic mechanism of electroconvulsive therapy (ECT) is unknown. Animal research supports a neurotrophic effect of ECT. To investigate a neurotrophic effect in humans, we examined whether plasma concentration of brain-derived neurotrophic factor (BDNF) increases in patients receiving ECT for major depression. Method: We conducted a prospective, self-controlled study of 15 patients with a DSM-IV diagnosis of major depressive episode who were referred for ECT at the University of Maryland Medical Center (Baltimore, Md.) between January 2004 and September 2005. Plasma BDNF concentration was measured by enzyme-linked immunosorbent assay before and during an acute course of ECT. Depression severity was measured using the 21-item Hamilton Rating Scale for Depression (HAM-D). Results: ECT resulted in a significant increase in plasma BDNF (Z = 2.897, p = .004) from a pre-ECT median of 84.9 pg/mL to a post-ECT median of 141.2 pg/mL. This change was accompanied by a significant decrease in HAM-D score (Z = 3.411, p = .001) from a pre-ECT median of 30.0 to a post-ECT median of 9.0. BDNF increased in 13 (86.7%) of 15 subjects. Conclusion: This is the first report of an increase in plasma BDNF concentration in patients receiving ECT. These preliminary results encourage further investigation of a neurotrophic mechanism for the antidepressant effect of ECT.

Original languageEnglish (US)
Pages (from-to)512-517
Number of pages6
JournalJournal of Clinical Psychiatry
Volume68
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: A pilot study in patients with major depression'. Together they form a unique fingerprint.

Cite this