TY - JOUR
T1 - Increased plasma cholestanol and 5α-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis
AU - Salen, G.
AU - Kwiterovich, P. O.
AU - Shefer, S.
AU - Tint, G. S.
AU - Horak, I.
AU - Shore, V.
AU - Dayal, B.
AU - Horak, E.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - We have measured plasma sterol, composition in 14 subjects with sitosterolemia and xanthomatosis. In addition to elevated plasma phytosterol (campesterol 16 ± 7 mg/dl and sitosterol 35 ± 16 mg/dl) and normal to moderately high cholesterol levels (258 ± 96 mg/dl), concentrations of 5α-saturated stanols, cholestanol, 5α-campestanol, and 5α-sitostanol were at least 10 times greater than controls. Diets contained plentiful quantities of cholesterol and plant sterols, but only trace amounts of cholestanol (<2 mg/day) and no detectable 5α-campestanol and 5α-sitostanol, which indicated that the 5α-saturated stanols were formed endogenously. Treatment with cholestyramine reduced plasma cholesterol and phytosterol levels by 45% and 5α-saturated stanols by 55%. These results indicate that abnormally high plasma concentrations of cholestanol, 5α-campestanol, and 5α-sitostanol are found in subjects with sitosterolemia and xanthomatosis, and that treatment with cholestyramine effectively reduced elevated plasma sterol levels.
AB - We have measured plasma sterol, composition in 14 subjects with sitosterolemia and xanthomatosis. In addition to elevated plasma phytosterol (campesterol 16 ± 7 mg/dl and sitosterol 35 ± 16 mg/dl) and normal to moderately high cholesterol levels (258 ± 96 mg/dl), concentrations of 5α-saturated stanols, cholestanol, 5α-campestanol, and 5α-sitostanol were at least 10 times greater than controls. Diets contained plentiful quantities of cholesterol and plant sterols, but only trace amounts of cholestanol (<2 mg/day) and no detectable 5α-campestanol and 5α-sitostanol, which indicated that the 5α-saturated stanols were formed endogenously. Treatment with cholestyramine reduced plasma cholesterol and phytosterol levels by 45% and 5α-saturated stanols by 55%. These results indicate that abnormally high plasma concentrations of cholestanol, 5α-campestanol, and 5α-sitostanol are found in subjects with sitosterolemia and xanthomatosis, and that treatment with cholestyramine effectively reduced elevated plasma sterol levels.
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M3 - Article
C2 - 3989379
AN - SCOPUS:0021856672
SN - 0022-2275
VL - 26
SP - 203
EP - 209
JO - Journal of Lipid Research
JF - Journal of Lipid Research
IS - 2
ER -