Increased Pacing Threshold After an Automatic Defibrillator Shock in Dogs: Effects of Class I and Class II Antiarrhythmic Drugs

THOMAS GUARNIERI, STEVEN D. DATORRE, HANSJURGEN BONDKE, JEFFREY BRINKER, STEVEN MYERS, JOSEPH H. LEVINE

Research output: Contribution to journalArticlepeer-review

Abstract

A high energy shock delivered by an automatic defibrillator may interfere with pacemaker function. To provide insight into the changes that occur in the threshold for ventricular pacing after the shock from an automatic defibrillator, we measured the time to capture during asynchronous ventricular pacing in dogs from endocardial or epicardial sites, after a 30 joule shock was delivered via conventional automatic defibrillator (AICD) patch electrodes. After a 30 joule shock, there was a transient Joss of ventricular capture. The duration of capture loss was related to current strength. During endocardial pacing at threshold current, the time to capture was 4.9 ± 1.2 s, whereas at current values twice threshold the time to capture from endocardial pacing was 2.2 ± 0.9 s. No difference was found between endocardial and epicardial pacing sites in the time to capture. To ascertain the mechanism of capture loss we: (1) examined the effects of converting the pacing catheter to a current sink (transiently shunting to ground); (2) altered excitability by an infusion of flecainide; (3) blocked sympathetic input (propranolol). No change in time to capture was noted by shunting the pacer to ground. After an infusion of flecainide the time to capture from endocardial pacing was significantly prolonged to 14.9 ± 2.2 s at the threshold value (P < .01) and 5.6 ± 2.1 s at twice threshold (P < .05). Conversely, intravenous propranolol had no effect on the time to capture after shock from endocardial pacing. These data indicate that there is a transient increase in pacing threshold after the shock from an automatic defibrillator. The duration of capture Joss is current‐dependent, and can be significantly increased by the presence of a class Ic antiarrhythmic drug.

Original languageEnglish (US)
Pages (from-to)1324-1330
Number of pages7
JournalPacing and Clinical Electrophysiology
Volume11
Issue number9
DOIs
StatePublished - Sep 1988

Keywords

  • antiarrhythmic drugs
  • capture loss
  • defibrillator
  • pacing threshold

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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