Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving

Dean F. Wong; Hiroto Kuwabara; David J. Schretlen; Katherine R. Bonson; Yun Zhou; Ayon Nandi; James R. Brašić; Alane S. Kimes; Marika A. Maris; Anil Kumar; Carlo Contoreggi; Jonathan Links; Monique Ernst; Olivier Rousset; Stephen Zukin; Anthony A. Grace; Charles Rohde; Donald R. Jasinski; Albert Gjedde; Edythe D. London

doi:10.1038/sj.npp.1301194

Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving

Dean F. Wong, Hiroto Kuwabara, David J. Schretlen, Katherine R. Bonson, Yun Zhou, Ayon Nandi, James R. Brašić, Alane S. Kimes, Marika A. Maris, Anil Kumar, Carlo Contoreggi, Jonathan Links, Monique Ernst, Olivier Rousset, Stephen Zukin, Anthony A. Grace, Charles Rohde, Donald R. Jasinski, Albert Gjedde, Edythe D. London

Research output: Contribution to journal › Article › peer-review

234 Scopus citations

Abstract

In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [ ¹¹C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

Original language	English (US)
Pages (from-to)	2716-2727
Number of pages	12
Journal	Neuropsychopharmacology
Volume	31
Issue number	12
DOIs	https://doi.org/10.1038/sj.npp.1301194
State	Published - Dec 4 2006

Keywords

Cocaine
Cue-elicited craving
Dopamine receptors
Dopamine release
PET neuroimaging
Receptor occupancy

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health

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Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., Contoreggi, C., Links, J., Ernst, M., Rousset, O., Zukin, S., Grace, A. A., Rohde, C., Jasinski, D. R., Gjedde, A., & London, E. D. (2006). Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. Neuropsychopharmacology, 31(12), 2716-2727. https://doi.org/10.1038/sj.npp.1301194

Wong, DF, Kuwabara, H , Schretlen, DJ, Bonson, KR, Zhou, Y, Nandi, A, Brašić, JR, Kimes, AS, Maris, MA, Kumar, A, Contoreggi, C, Links, J, Ernst, M, Rousset, O, Zukin, S, Grace, AA, Rohde, C, Jasinski, DR, Gjedde, A & London, ED 2006, 'Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving', Neuropsychopharmacology, vol. 31, no. 12, pp. 2716-2727. https://doi.org/10.1038/sj.npp.1301194

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title = "Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving",

abstract = "In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [ 11C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.",

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author = "Wong, {Dean F.} and Hiroto Kuwabara and Schretlen, {David J.} and Bonson, {Katherine R.} and Yun Zhou and Ayon Nandi and Bra{\v s}i{\'c}, {James R.} and Kimes, {Alane S.} and Maris, {Marika A.} and Anil Kumar and Carlo Contoreggi and Jonathan Links and Monique Ernst and Olivier Rousset and Stephen Zukin and Grace, {Anthony A.} and Charles Rohde and Jasinski, {Donald R.} and Albert Gjedde and London, {Edythe D.}",

note = "Funding Information: Grant support: PHS Grant NIH K24DA00412, DA11080, AA12839, NS 38927 to DW, Danish National Science Foundation Center of Excellence grant to AG. Special Thanks to L Sims, M Thomas, B Gay, A Crabb, RF Dannals, H Ravert, W Mathews, M Pomper, and S Tata for scientific and technical assistance. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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AU - Zhou, Yun

AU - Nandi, Ayon

AU - Brašić, James R.

AU - Kimes, Alane S.

AU - Maris, Marika A.

AU - Kumar, Anil

AU - Contoreggi, Carlo

AU - Links, Jonathan

AU - Ernst, Monique

AU - Rousset, Olivier

AU - Zukin, Stephen

AU - Grace, Anthony A.

AU - Rohde, Charles

AU - Jasinski, Donald R.

AU - Gjedde, Albert

AU - London, Edythe D.

N1 - Funding Information: Grant support: PHS Grant NIH K24DA00412, DA11080, AA12839, NS 38927 to DW, Danish National Science Foundation Center of Excellence grant to AG. Special Thanks to L Sims, M Thomas, B Gay, A Crabb, RF Dannals, H Ravert, W Mathews, M Pomper, and S Tata for scientific and technical assistance. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2006/12/4

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N2 - In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [ 11C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

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Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving

Abstract

Keywords

ASJC Scopus subject areas

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