Abstract
Individuals with sarcoidosis were evaluated for preferential usage of T cells with the γδ-positive (+) type of T cell antigen receptor. Compared with normal subjects (n = 19), the group with sarcoidosis had increased numbers of CD3+ αβ-negative (-) T cells in the blood (normal, 58±12 cells/μl; sarcoid, 192±45 cells/μl, P < 0.05) and in the epithelial lining fluid of the lung (normal, 78±14 cells/μl; sarcoid, 240±60 cells/μl, P < 0.04) and a concomitant elevated number of blood and lung CD3+ γδ+ T cells, owing to a striking increase in the number of CD3+ γδ+ T cells in a subgroup (7 of 20) of sarcoid individuals. The elevated numbers of sarcoid blood γδ+ T lymphocytes were mostly TiγA+ and δTCS1-, a pattern also seen in normal individuals, consistent with the majority of γδ+ T cells expressing one γ-chain variable region, Vγ9. The observation of an increase in the total γδ+ T cell numbers in a sarcoid subgroup suggests that various specific stimuli may trigger the expansion of different T cell subpopulations within different groups of individuals with sarcoidosis.
Original language | English (US) |
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Pages (from-to) | 1353-1361 |
Number of pages | 9 |
Journal | Journal of Clinical Investigation |
Volume | 85 |
Issue number | 5 |
DOIs | |
State | Published - May 1990 |
Externally published | Yes |
Keywords
- Lung
- Lymphocyte
- Sarcoidosis
- T cell receptor
ASJC Scopus subject areas
- General Medicine