Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients

Cathy G. Mcallister, Mark Hyman Rapaport, David Pickar, Teresa A. Podruchny, George Christison, Larry D. Alphs, Steven M. Paul

Research output: Contribution to journalArticle

Abstract

Autoimmune mechanisms have been postulated to play a role in the pathogenesis of schizophrenia. Recently, increased numbers of B lymphocytes expressing the CD5 (Leu-1) surface antigen have been observed in patients with certain autoimmune diseases. In the present study, approximately 30% of schizophrenic patients (11/34) were found by cytofluorometric methods to have similarly increased levels of circulating CD5 B cells compared with 6% (2/33) of healthy individuals and 5% (1/20) of patients with bipolar affective disorder. In schizophrenic patients with a “high” CD5 B-cell phenotype, the percentage of B cells expressing the CD5 surface marker (mean + SEM, 52.4% + 3.5%) was comparable to that reported for patients with rheumatoid arthritis and significantly greater than that reported for patients with bipolar affective disorder (25.7%±2.5%) and healthy controls (31.0% ±1.8%). Schizophrenic patients with high levels of CD5 B cells had increased numbers of total B cells compared with control subjects and patients with low levels of CD5 B cells. An elevation in CD5+ B cells may delineate a subgroup of schizophrenic patients whose disease has an underlying autoimmune and/or genetic cause.

Original languageEnglish (US)
Pages (from-to)890-894
Number of pages5
JournalArchives of General Psychiatry
Volume46
Issue number10
DOIs
StatePublished - 1989
Externally publishedYes

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B-Lymphocytes
Mood Disorders
Bipolar Disorder
CD5 Antigens
Surface Antigens
Cells
Autoimmune Diseases
Rheumatoid Arthritis
Schizophrenia
Phenotype

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Mcallister, C. G., Rapaport, M. H., Pickar, D., Podruchny, T. A., Christison, G., Alphs, L. D., & Paul, S. M. (1989). Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients. Archives of General Psychiatry, 46(10), 890-894. https://doi.org/10.1001/archpsyc.1989.01810100032006

Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients. / Mcallister, Cathy G.; Rapaport, Mark Hyman; Pickar, David; Podruchny, Teresa A.; Christison, George; Alphs, Larry D.; Paul, Steven M.

In: Archives of General Psychiatry, Vol. 46, No. 10, 1989, p. 890-894.

Research output: Contribution to journalArticle

Mcallister, CG, Rapaport, MH, Pickar, D, Podruchny, TA, Christison, G, Alphs, LD & Paul, SM 1989, 'Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients', Archives of General Psychiatry, vol. 46, no. 10, pp. 890-894. https://doi.org/10.1001/archpsyc.1989.01810100032006
Mcallister CG, Rapaport MH, Pickar D, Podruchny TA, Christison G, Alphs LD et al. Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients. Archives of General Psychiatry. 1989;46(10):890-894. https://doi.org/10.1001/archpsyc.1989.01810100032006
Mcallister, Cathy G. ; Rapaport, Mark Hyman ; Pickar, David ; Podruchny, Teresa A. ; Christison, George ; Alphs, Larry D. ; Paul, Steven M. / Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients. In: Archives of General Psychiatry. 1989 ; Vol. 46, No. 10. pp. 890-894.
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