Abstract
In mice with 'diffuse' hemoglobin (Hb), the decrease in the proportion of minor Hb during ontogeny qualitatively resembles the decline observed in human Hb F. Since Hb F reappears during some forms of erythroid stress, we investigated the effect of hematopoietic stress on minor Hb in DBA/2 mice. The stresses were acetylphenylhydrazine-induced hemolysis, phlebotomy, or infection with Friend erythroleukemia virus. Recovery from anemia was associated with a transient increase in the synthesis of minor Hb similar to the reappearance of Hb F in man. Minor Hb synthesis also increased during the evolution of erythroleukemia induced by both the anemic and the polycythemic strains of virus. Thus, the mouse model can be used to study Hb regulation, since changes in the modulation of minor Hb synthesis occur under conditions which are associated with alterations of Hb F synthesis in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 754-760 |
| Number of pages | 7 |
| Journal | Experimental Hematology |
| Volume | 10 |
| Issue number | 9 |
| State | Published - 1982 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Genetics
- Hematology
- Oncology
- Transplantation
Cite this
Increased mouse minor hemoglobin during erythroid stress : A model for hemoglobin regulation. / Alter, B. P.; Campbell, A. S.; Holland, J. G.; Friend, C.
In: Experimental Hematology, Vol. 10, No. 9, 1982, p. 754-760.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased mouse minor hemoglobin during erythroid stress
T2 - A model for hemoglobin regulation
AU - Alter, B. P.
AU - Campbell, A. S.
AU - Holland, J. G.
AU - Friend, C.
PY - 1982
Y1 - 1982
N2 - In mice with 'diffuse' hemoglobin (Hb), the decrease in the proportion of minor Hb during ontogeny qualitatively resembles the decline observed in human Hb F. Since Hb F reappears during some forms of erythroid stress, we investigated the effect of hematopoietic stress on minor Hb in DBA/2 mice. The stresses were acetylphenylhydrazine-induced hemolysis, phlebotomy, or infection with Friend erythroleukemia virus. Recovery from anemia was associated with a transient increase in the synthesis of minor Hb similar to the reappearance of Hb F in man. Minor Hb synthesis also increased during the evolution of erythroleukemia induced by both the anemic and the polycythemic strains of virus. Thus, the mouse model can be used to study Hb regulation, since changes in the modulation of minor Hb synthesis occur under conditions which are associated with alterations of Hb F synthesis in humans.
AB - In mice with 'diffuse' hemoglobin (Hb), the decrease in the proportion of minor Hb during ontogeny qualitatively resembles the decline observed in human Hb F. Since Hb F reappears during some forms of erythroid stress, we investigated the effect of hematopoietic stress on minor Hb in DBA/2 mice. The stresses were acetylphenylhydrazine-induced hemolysis, phlebotomy, or infection with Friend erythroleukemia virus. Recovery from anemia was associated with a transient increase in the synthesis of minor Hb similar to the reappearance of Hb F in man. Minor Hb synthesis also increased during the evolution of erythroleukemia induced by both the anemic and the polycythemic strains of virus. Thus, the mouse model can be used to study Hb regulation, since changes in the modulation of minor Hb synthesis occur under conditions which are associated with alterations of Hb F synthesis in humans.
UR - http://www.scopus.com/inward/record.url?scp=0019907197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019907197&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 754
EP - 760
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 9
ER -