Increased mouse minor hemoglobin during erythroid stress: A model for hemoglobin regulation

B. P. Alter, A. S. Campbell, J. G. Holland, C. Friend

Research output: Contribution to journalArticle

Abstract

In mice with 'diffuse' hemoglobin (Hb), the decrease in the proportion of minor Hb during ontogeny qualitatively resembles the decline observed in human Hb F. Since Hb F reappears during some forms of erythroid stress, we investigated the effect of hematopoietic stress on minor Hb in DBA/2 mice. The stresses were acetylphenylhydrazine-induced hemolysis, phlebotomy, or infection with Friend erythroleukemia virus. Recovery from anemia was associated with a transient increase in the synthesis of minor Hb similar to the reappearance of Hb F in man. Minor Hb synthesis also increased during the evolution of erythroleukemia induced by both the anemic and the polycythemic strains of virus. Thus, the mouse model can be used to study Hb regulation, since changes in the modulation of minor Hb synthesis occur under conditions which are associated with alterations of Hb F synthesis in humans.

Original languageEnglish (US)
Pages (from-to)754-760
Number of pages7
JournalExperimental Hematology
Volume10
Issue number9
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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