Increased Mortality Associated With Vitamin A Deficiency During Human Immunodeficiency Virus Type 1 Infection

Richard David Semba, Neil M H Graham, Waleska T. Caiaffa, Joseph Bernard Margolick, Liliana Clement, David Vlahov

Research output: Contribution to journalArticle

Abstract

Objective: To determine whether plasma vitamin A levels are associated with immunologic status and clinical outcome during human immunodeficiency virus type 1 (HIV-1) infection. Patients and Patients and Methods: Analysis of vitamin A levels, CD4 T cells, complete blood cell count, and serologic markers for liver disease in a random subsample of 179 subjects from a cohort of more than 2000 intravenous drug users with longitudinal follow-up to determine survival. Results: Mean (±SE) follow-up time was 22.8±1.1 months, and 15 subjects died during follow-up. More than 15% of the HIV-l-seropositive individuals had plasma vitamin A levels less than 1.05 μmol/L, a level consistent with vitamin A deficiency. The HIV-l-seropositive individuals had lower mean plasma vitamin A levels than HIV-l-seronegative individuals (P

Original languageEnglish (US)
Pages (from-to)2149-2154
Number of pages6
JournalArchives of Internal Medicine
Volume153
Issue number18
DOIs
StatePublished - 1993

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Vitamin A Deficiency
Vitamin A
HIV-1
Blood Cell Count
Mortality
HIV
Infection
Virus Diseases
Drug Users
Liver Diseases
T-Lymphocytes
Survival

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Increased Mortality Associated With Vitamin A Deficiency During Human Immunodeficiency Virus Type 1 Infection. / Semba, Richard David; Graham, Neil M H; Caiaffa, Waleska T.; Margolick, Joseph Bernard; Clement, Liliana; Vlahov, David.

In: Archives of Internal Medicine, Vol. 153, No. 18, 1993, p. 2149-2154.

Research output: Contribution to journalArticle

Semba, Richard David ; Graham, Neil M H ; Caiaffa, Waleska T. ; Margolick, Joseph Bernard ; Clement, Liliana ; Vlahov, David. / Increased Mortality Associated With Vitamin A Deficiency During Human Immunodeficiency Virus Type 1 Infection. In: Archives of Internal Medicine. 1993 ; Vol. 153, No. 18. pp. 2149-2154.
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