Increased metabolic clearance of acetaminophen with oral contraceptive use

Darrell R. Abernethy, Marcia Divoll, Hermann R. Ochs, Barbara Ameer, David J. Greenblatt

Research output: Contribution to journalArticle

Abstract

The effect of chronic low-dose oral contraceptive steroid use on the pharmacokinetics of intravenous acetaminophen was determined. Eight women using low-dose (under 50 [mu]g) estrogen oral contraceptive steroid for more than 3 months were matched for age and weight (mean age, 25.9 years; mean weight, 58.3 kg) with 8 female controls not using the steroid (mean age, 26.0 years; mean weight, 55.5 kg). No subject was taking other drugs. Oral contraceptive steroid subjects had a lower elimination half-life of acetaminophen (2.12 hours) than controls (2.71 hours) (P<.005). Volume of distribution was similar for both groups (oral contraceptive group, 1.04 liters/kg; controls, 0.96 liters/kg; NS). Total metabolic clearance was significantly higher in oral contraceptive subjects (5.81 ml/min/kg, versus 4.12 ml/min/kg for controls; P<.02). As volume of distribution and body weight are similar for both groups, the decrease in acetaminophen elimination half-life among contraceptive steroid users is the result of increased total metabolic clearance. Thus, low-dose estrogen oral contraceptive steroid may stimulate the metabolism of a conjugatively metabolized drug such as acetaminophen, in contrast to contraceptive steroid impairment of the clearance of some oxidatively metabolized drugs, with antipyrine being the prototype.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalObstetrics and gynecology
Volume60
Issue number3
StatePublished - Sep 1982

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Abernethy, D. R., Divoll, M., Ochs, H. R., Ameer, B., & Greenblatt, D. J. (1982). Increased metabolic clearance of acetaminophen with oral contraceptive use. Obstetrics and gynecology, 60(3), 338-341.