Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis

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Abstract

Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF: plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P=.003) and astrocyte activation (glial fibrillary acidic protein; P=.019 and P=.031 in white and gray matter, respectively). The results suggest that the CSF: plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.

Original languageEnglish (US)
Pages (from-to)1015-1021
Number of pages7
JournalJournal of Infectious Diseases
Volume184
Issue number8
DOIs
StatePublished - Oct 15 2001

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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