Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis

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Abstract

Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF: plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P=.003) and astrocyte activation (glial fibrillary acidic protein; P=.019 and P=.031 in white and gray matter, respectively). The results suggest that the CSF: plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.

Original languageEnglish (US)
Pages (from-to)1015-1021
Number of pages7
JournalJournal of Infectious Diseases
Volume184
Issue number8
DOIs
StatePublished - Oct 15 2001

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Simian Immunodeficiency Virus
Chemotactic Factors
Encephalitis
Cerebrospinal Fluid
Macrophages
Macaca
Proteins
Astrocytes
Brain
HIV
Macrophage Activation
Central Nervous System Diseases
Glial Fibrillary Acidic Protein
Microglia
Messenger RNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

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title = "Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis",
abstract = "Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF: plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P=.003) and astrocyte activation (glial fibrillary acidic protein; P=.019 and P=.031 in white and gray matter, respectively). The results suggest that the CSF: plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.",
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AU - Coleman, G. D.

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AU - Adams, Robert John

AU - Tarwater, Patrick

AU - Fox, K.

AU - Clements, Janice E

PY - 2001/10/15

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N2 - Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF: plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P=.003) and astrocyte activation (glial fibrillary acidic protein; P=.019 and P=.031 in white and gray matter, respectively). The results suggest that the CSF: plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.

AB - Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF: plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P=.003) and astrocyte activation (glial fibrillary acidic protein; P=.019 and P=.031 in white and gray matter, respectively). The results suggest that the CSF: plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.

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