Abstract
With enzyme immunoassay, maternal serum chorionic gonadotropin (MShCG) level was determined in 58 pregnancies affected with fetal homozygous alpha-thalassemia 1. In 40 pregnancies with a gestational age of 10 to 14 weeks, 8 (20%) had an MShCG level above 2.5 multiples of the median (MoM); while in the other 18 pregnancies with a gestational age of 15 to 23 weeks, 14 (78%) had a level above 2.5 MoMs and none had a level below the median. Homozygous alpha-thalassemia 1 of the fetus was associated with an elevated MShCG. Therefore in second-trimester screening for Down's syndrome by measurement of MShCG, homozygous alpha-thalassemia 1 should also be considered if elevated MShCG levels are found.
Original language | English (US) |
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Pages (from-to) | 113-117 |
Number of pages | 5 |
Journal | Archives of Gynecology and Obstetrics |
Volume | 255 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1994 |
Externally published | Yes |
Keywords
- Alpha-thalassemia
- Maternal serum human chorionic gonadotropin
- Maternal serum screening
ASJC Scopus subject areas
- Obstetrics and Gynecology