Increased level of second trimester maternal serum chorionic gonadotropin in pregnancy with a fetus affected by homozygous alpha-thalassemia 1

L. H. Tseng, H. L. Hwa, S. M. Chuang, T. Y. Lee, T. M. Ko

Research output: Contribution to journalArticlepeer-review

Abstract

With enzyme immunoassay, maternal serum chorionic gonadotropin (MShCG) level was determined in 58 pregnancies affected with fetal homozygous alpha-thalassemia 1. In 40 pregnancies with a gestational age of 10 to 14 weeks, 8 (20%) had an MShCG level above 2.5 multiples of the median (MoM); while in the other 18 pregnancies with a gestational age of 15 to 23 weeks, 14 (78%) had a level above 2.5 MoMs and none had a level below the median. Homozygous alpha-thalassemia 1 of the fetus was associated with an elevated MShCG. Therefore in second-trimester screening for Down's syndrome by measurement of MShCG, homozygous alpha-thalassemia 1 should also be considered if elevated MShCG levels are found.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalArchives of Gynecology and Obstetrics
Volume255
Issue number3
DOIs
StatePublished - Jul 1994
Externally publishedYes

Keywords

  • Alpha-thalassemia
  • Maternal serum human chorionic gonadotropin
  • Maternal serum screening

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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