Increased intragallbladder pressure response to cholecystokinin-octapeptide following vagotomy and pyloroplasty

Henry A. Pitt, Jeffrey E. Doty, Lawrence DenBesten

Research output: Contribution to journalArticle

Abstract

One of the late effects of truncal vagotomy is gallbladder dilatation. However, the early physiologic mechanisms responsible for this phenomenon have not been clearly elucidated. Therefore, the hypothesis that truncal vagotomy alters the gallbladder's or cystic duct's response to hormonal stimulation was tested. Adult male prairie dogs underwent either truncal vagotomy and pyloroplasty or sham laparotomy. All animals were then fed a trace-cholesterol (nonlithogenic) diet for 3 months. In acute terminal experiments the gallbladder was aspirated and cannulated with a pressure-monitored perfusion catheter. The common bile duct was cannulated with a drainage catheter. Aspirated gallbladder volume and cystic duct closing pressure were the same in vagotomized and sham animals. Unstimulated intragallbladder pressure and cystic duct outflow resistance were also the same in both groups. However, during an intravenous infusion (10 ng/kg/min) of cholecystokinin-octapeptide (CCK-OP), the maximal intragallbladder pressure increase was greater (P <0.01) in vagotomized animals (3.50 ± 0.41 mm Hg) than in sham animals (1.63 ± 0.36 mm Hg). Intragallbladder pressure remained significantly higher (P <0.05) in vagotomized animals throughout the 30-min infusion of CCK-OP. Despite increased intragallbladder pressure, gallbladder emptying was unaffected by vagotomy. It is concluded that altered gallbladder or cystic duct hormonal response is an early effect of vagotomy that may result in gallbladder dilatation.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalJournal of Surgical Research
Volume35
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

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Sincalide
Vagotomy
Gallbladder
Cystic Duct
Truncal Vagotomy
Pressure
Dilatation
Catheters
Gallbladder Emptying
Sciuridae
Common Bile Duct
Intravenous Infusions
Laparotomy
Drainage
Perfusion
Cholesterol
Diet

ASJC Scopus subject areas

  • Surgery

Cite this

Increased intragallbladder pressure response to cholecystokinin-octapeptide following vagotomy and pyloroplasty. / Pitt, Henry A.; Doty, Jeffrey E.; DenBesten, Lawrence.

In: Journal of Surgical Research, Vol. 35, No. 4, 1983, p. 325-331.

Research output: Contribution to journalArticle

Pitt, Henry A. ; Doty, Jeffrey E. ; DenBesten, Lawrence. / Increased intragallbladder pressure response to cholecystokinin-octapeptide following vagotomy and pyloroplasty. In: Journal of Surgical Research. 1983 ; Vol. 35, No. 4. pp. 325-331.
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