TY - JOUR
T1 - Increased integration between default mode and task-relevant networks in children with ADHD is associated with impaired response control
AU - Duffy, Kelly A.
AU - Rosch, Keri S.
AU - Nebel, Mary Beth
AU - Seymour, Karen E.
AU - Lindquist, Martin A.
AU - Pekar, James J.
AU - Mostofsky, Stewart H.
AU - Cohen, Jessica R.
N1 - Funding Information:
This work was supported by National Institutes of Health, USA [grant numbers R01MH085328 and R01MH078160 to SHM, R00MH102349 to JRC, K23MH101322 to KSR, K23MH107734 to KES, R01EB016061 and R01EB026549 to MAL, K01MH109766 to MBN, T32DA050560 to KAD, and 5P41EB015909 to JJP]; Johns Hopkins University School of Medicine Institute for Clinical and Translational Research NIH/National Center for Research Resources Clinical and Translational Science Award program, USA [grant number UL1TR000424 to KSR and KES]; and the Brain and Behavior Research Foundation, USA [NARSAD Young Investigators award to KES]. We would also like to thank Teague R. Henry for statistical consulting.
Publisher Copyright:
© 2021 The Authors
PY - 2021/8
Y1 - 2021/8
N2 - Default mode network (DMN) dysfunction is theorized to play a role in attention lapses and task errors in children with attention-deficit/hyperactivity disorder (ADHD). In ADHD, the DMN is hyperconnected to task-relevant networks, and both increased functional connectivity and reduced activation are related to poor task performance. The current study extends existing literature by considering interactions between the DMN and task-relevant networks from a brain network perspective and by assessing how these interactions relate to response control. We characterized both static and time-varying functional brain network organization during the resting state in 43 children with ADHD and 43 age-matched typically developing (TD) children. We then related aspects of network integration to go/no-go performance. We calculated participation coefficient (PC), a measure of a region's inter-network connections, for regions of the DMN, canonical cognitive control networks (fronto-parietal, salience/cingulo-opercular), and motor-related networks (somatomotor, subcortical). Mean PC was higher in children with ADHD as compared to TD children, indicating greater integration across networks. Further, higher and less variable PC was related to greater commission error rate in children with ADHD. Together, these results inform our understanding of the role of the DMN and its interactions with task-relevant networks in response control deficits in ADHD.
AB - Default mode network (DMN) dysfunction is theorized to play a role in attention lapses and task errors in children with attention-deficit/hyperactivity disorder (ADHD). In ADHD, the DMN is hyperconnected to task-relevant networks, and both increased functional connectivity and reduced activation are related to poor task performance. The current study extends existing literature by considering interactions between the DMN and task-relevant networks from a brain network perspective and by assessing how these interactions relate to response control. We characterized both static and time-varying functional brain network organization during the resting state in 43 children with ADHD and 43 age-matched typically developing (TD) children. We then related aspects of network integration to go/no-go performance. We calculated participation coefficient (PC), a measure of a region's inter-network connections, for regions of the DMN, canonical cognitive control networks (fronto-parietal, salience/cingulo-opercular), and motor-related networks (somatomotor, subcortical). Mean PC was higher in children with ADHD as compared to TD children, indicating greater integration across networks. Further, higher and less variable PC was related to greater commission error rate in children with ADHD. Together, these results inform our understanding of the role of the DMN and its interactions with task-relevant networks in response control deficits in ADHD.
KW - ADHD
KW - Default mode network
KW - Functional connectivity
KW - Response control
KW - Resting state
KW - Task-relevant networks
UR - http://www.scopus.com/inward/record.url?scp=85110058755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110058755&partnerID=8YFLogxK
U2 - 10.1016/j.dcn.2021.100980
DO - 10.1016/j.dcn.2021.100980
M3 - Article
C2 - 34252881
AN - SCOPUS:85110058755
VL - 50
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
SN - 1878-9293
M1 - 100980
ER -