Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia

Mia W. Doron, Rita A. Makhlouf, Vern L. Katz, Edward Lawson, Alan D. Stiles

Research output: Contribution to journalArticle

Abstract

Neutropenia is often found at birth in infants born to mothers with preeclampsia, and is most likely present in utero. To determine whether this neutropenia is associated with an increased incidence of early-onset sepsis, we reviewed the hospital records of 301 low birth weight infants of mothers with preeclampsia. Early-onset sepsis was proved if the result of a culture of blood or cerebrospinal fluid in the first 48 hours of life was positive, or presumed if culture results were negative but two or more clinical signs of sepsis were present and the attending neonatologist belleved that an infant was infected and needed at least 7 days of antibiotic therapy. Forty-eight percent of low birth weight infants of mothers with preeclampsia had neutropenia at less than 12 hours of age. Infants with neutropenia had mothers with more severe preeclampsia, were more premature (30 weeks vs 32 weeks), weighed less (1097 gm vs 1615 gm), and were more likely to be small for gestational age. Although maternal and obstetric risk factors for infection were less common in the group with neutropenia, rates of proven or presumed early-onset sepsis were higher (14% vs 2%; p

Original languageEnglish (US)
Pages (from-to)452-458
Number of pages7
JournalJournal of Pediatrics
Volume125
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Pre-Eclampsia
Neutropenia
Sepsis
Mothers
Parturition
Incidence
Low Birth Weight Infant
Hospital Records
Gestational Age
Obstetrics
Cerebrospinal Fluid
Anti-Bacterial Agents
Infection
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia. / Doron, Mia W.; Makhlouf, Rita A.; Katz, Vern L.; Lawson, Edward; Stiles, Alan D.

In: Journal of Pediatrics, Vol. 125, No. 3, 1994, p. 452-458.

Research output: Contribution to journalArticle

Doron, Mia W. ; Makhlouf, Rita A. ; Katz, Vern L. ; Lawson, Edward ; Stiles, Alan D. / Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia. In: Journal of Pediatrics. 1994 ; Vol. 125, No. 3. pp. 452-458.
@article{71b7deab28cf4a7997f620f7b2ae8435,
title = "Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia",
abstract = "Neutropenia is often found at birth in infants born to mothers with preeclampsia, and is most likely present in utero. To determine whether this neutropenia is associated with an increased incidence of early-onset sepsis, we reviewed the hospital records of 301 low birth weight infants of mothers with preeclampsia. Early-onset sepsis was proved if the result of a culture of blood or cerebrospinal fluid in the first 48 hours of life was positive, or presumed if culture results were negative but two or more clinical signs of sepsis were present and the attending neonatologist belleved that an infant was infected and needed at least 7 days of antibiotic therapy. Forty-eight percent of low birth weight infants of mothers with preeclampsia had neutropenia at less than 12 hours of age. Infants with neutropenia had mothers with more severe preeclampsia, were more premature (30 weeks vs 32 weeks), weighed less (1097 gm vs 1615 gm), and were more likely to be small for gestational age. Although maternal and obstetric risk factors for infection were less common in the group with neutropenia, rates of proven or presumed early-onset sepsis were higher (14{\%} vs 2{\%}; p",
author = "Doron, {Mia W.} and Makhlouf, {Rita A.} and Katz, {Vern L.} and Edward Lawson and Stiles, {Alan D.}",
year = "1994",
doi = "10.1016/S0022-3476(05)83294-9",
language = "English (US)",
volume = "125",
pages = "452--458",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia

AU - Doron, Mia W.

AU - Makhlouf, Rita A.

AU - Katz, Vern L.

AU - Lawson, Edward

AU - Stiles, Alan D.

PY - 1994

Y1 - 1994

N2 - Neutropenia is often found at birth in infants born to mothers with preeclampsia, and is most likely present in utero. To determine whether this neutropenia is associated with an increased incidence of early-onset sepsis, we reviewed the hospital records of 301 low birth weight infants of mothers with preeclampsia. Early-onset sepsis was proved if the result of a culture of blood or cerebrospinal fluid in the first 48 hours of life was positive, or presumed if culture results were negative but two or more clinical signs of sepsis were present and the attending neonatologist belleved that an infant was infected and needed at least 7 days of antibiotic therapy. Forty-eight percent of low birth weight infants of mothers with preeclampsia had neutropenia at less than 12 hours of age. Infants with neutropenia had mothers with more severe preeclampsia, were more premature (30 weeks vs 32 weeks), weighed less (1097 gm vs 1615 gm), and were more likely to be small for gestational age. Although maternal and obstetric risk factors for infection were less common in the group with neutropenia, rates of proven or presumed early-onset sepsis were higher (14% vs 2%; p

AB - Neutropenia is often found at birth in infants born to mothers with preeclampsia, and is most likely present in utero. To determine whether this neutropenia is associated with an increased incidence of early-onset sepsis, we reviewed the hospital records of 301 low birth weight infants of mothers with preeclampsia. Early-onset sepsis was proved if the result of a culture of blood or cerebrospinal fluid in the first 48 hours of life was positive, or presumed if culture results were negative but two or more clinical signs of sepsis were present and the attending neonatologist belleved that an infant was infected and needed at least 7 days of antibiotic therapy. Forty-eight percent of low birth weight infants of mothers with preeclampsia had neutropenia at less than 12 hours of age. Infants with neutropenia had mothers with more severe preeclampsia, were more premature (30 weeks vs 32 weeks), weighed less (1097 gm vs 1615 gm), and were more likely to be small for gestational age. Although maternal and obstetric risk factors for infection were less common in the group with neutropenia, rates of proven or presumed early-onset sepsis were higher (14% vs 2%; p

UR - http://www.scopus.com/inward/record.url?scp=0027963288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027963288&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(05)83294-9

DO - 10.1016/S0022-3476(05)83294-9

M3 - Article

C2 - 8071757

AN - SCOPUS:0027963288

VL - 125

SP - 452

EP - 458

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 3

ER -