TY - JOUR
T1 - Increased hepatitis C virus load among injection drug users infected with human immunodeficiency virus and human T lymphotropic virus type II
AU - Hisada, Michie
AU - Chatterjee, Nilanjan
AU - Zhang, Mingdong
AU - Battjes, Robert J.
AU - Goedert, James J.
PY - 2003/9/15
Y1 - 2003/9/15
N2 - Coinfection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and/or human T-lymphotropic virus type II (HTLV-II) is common among drug users. We compared HCV RNA detection and load in a cohort of 6570 injection drug users from 9 US cities during 1987-1991. Of 385 subjects selected from 16 strata by sex, race (black or nonblack), and HIV/HTLV-II group (HIV positive [HIV+]/HTLV-II+, HIV+/HTLV-II negative [HTLV-II-], HIV-/HTLV-II+, and HIV -/HTLV-II-), 376 had HCV antibodies, of whom 305 had detectable HCV load. HCV RNA detection was unrelated to sex, race, and virus groups, but differed by study site. The mean HCV load was 5.4 log10 IU/mL and was 0.24 log10 higher in men than in women. Virus load increment with HIV or HTLV-II infection was higher among white subjects than among other subjects. Compared with HIV-/HTLV-II- subjects, virus load was 0.50, 0.22, and 0.56 log10 higher in HIV+/HTLV-II-, HIV-/HTLV-II+, and HIV+/HTLV-II+ subjects, respectively. HTLV-II infection significantly increased HCV load in white subjects but not in other racial groups.
AB - Coinfection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and/or human T-lymphotropic virus type II (HTLV-II) is common among drug users. We compared HCV RNA detection and load in a cohort of 6570 injection drug users from 9 US cities during 1987-1991. Of 385 subjects selected from 16 strata by sex, race (black or nonblack), and HIV/HTLV-II group (HIV positive [HIV+]/HTLV-II+, HIV+/HTLV-II negative [HTLV-II-], HIV-/HTLV-II+, and HIV -/HTLV-II-), 376 had HCV antibodies, of whom 305 had detectable HCV load. HCV RNA detection was unrelated to sex, race, and virus groups, but differed by study site. The mean HCV load was 5.4 log10 IU/mL and was 0.24 log10 higher in men than in women. Virus load increment with HIV or HTLV-II infection was higher among white subjects than among other subjects. Compared with HIV-/HTLV-II- subjects, virus load was 0.50, 0.22, and 0.56 log10 higher in HIV+/HTLV-II-, HIV-/HTLV-II+, and HIV+/HTLV-II+ subjects, respectively. HTLV-II infection significantly increased HCV load in white subjects but not in other racial groups.
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U2 - 10.1086/377585
DO - 10.1086/377585
M3 - Article
C2 - 12964121
AN - SCOPUS:0141840749
SN - 0022-1899
VL - 188
SP - 891
EP - 897
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -