Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma

Kathleen B. Schwarz, Michael Kew, Andrew Klein, Ross A. Abrams, James Sitzmann, Lawrence Jones, Savitri Sharma, R. S. Britton, Adrian M. Di Bisceglie, John Groopman

Research output: Contribution to journalArticle

Abstract

Since oxidative DNA damage plays a role in experimental carcinogen-induced cancers, the purpose of the present study was to determine if hepatic oxidative DNA damage was increased in patients with HCC compared to patients with benign hepatic tumors or hepatic metastases (non-HCC) or to patients with end-stage alcoholic liver disease undergoing liver transplantation. Oxidative DNA damage was assessed by 8-hydroxy-2′-deoxyguanosine (8-OH-dG). Results showed that peritumoral 8-OH-dG was markedly increased in HCC (N=51) (180±74 vs 32±58-OH-dG/106dG for tumor, P<0.005) in contrast to patients with non-HCC (N=17), in whom the peritumoral 8-OH-dG did not differ from that in tumor (39±7 vs. 31±108-OH-dG/106dG). Oxidative DNA damage can be both mutagenic and carcinogenic; our data suggested it will be important in future studies to determine the chronology of this type of liver injury relative to hepatocarcinogenesis.

Original languageEnglish (US)
Pages (from-to)2173-2178
Number of pages6
JournalDigestive diseases and sciences
Volume46
Issue number10
DOIs
StatePublished - Oct 22 2001

Keywords

  • 8-hydro-2′-deoxyguanosine
  • Hepatitis B virus
  • Hepatitis C virus

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Schwarz, K. B., Kew, M., Klein, A., Abrams, R. A., Sitzmann, J., Jones, L., Sharma, S., Britton, R. S., Di Bisceglie, A. M., & Groopman, J. (2001). Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma. Digestive diseases and sciences, 46(10), 2173-2178. https://doi.org/10.1023/A:1011958814371