TY - JOUR
T1 - Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women
AU - Augenbraun, Michael
AU - Feldman, Joseph
AU - Chirgwin, Keith
AU - Zenilman, Jonathan
AU - Clarke, Lorraine
AU - DeHovitz, Jack
AU - Landesman, Sheldon
AU - Minkoff, Howard
PY - 1995/12/1
Y1 - 1995/12/1
N2 - Objective: To compare the prevalence of genital herpes simplex virus type 2 (HSV-2) shedding in human immunodeficiency virus (HIV)-seropositive women and HIV-seronegative women. Design: Cross-sectional study Setting: A major inner-city medical center. Patients: 106 women who were HIV-seropositive and HSV-2-seropositive and 70 women who were HIV-seronegative and HSV-2-seropositive were enrolled from various primary care settings. Measurements: Herpes simplex virus type 2 antibody determinations were done for all patients. Regardless of symptoms, vulvar and cervical HSV cultures were obtained from all HIV-seropositive women and from a randomly selected subgroup of HIV-seronegative women. Results: The prevalence of HSV-2 shedding was nearly four times greater Jn HIV-seropositive than in HIV-seronegative women (13.2% compared with 3.6%; P = 0.04; odds ratio, 4.1 [95% Cl, 1.0 to 27.4]) when the serum antibody for HSV-2 was present. Seventy-nine percent of viral shedding among HIV-seropositive women was asymptomatic. Overall viral shedding increased significantly as the CD4 cell count decreased. Conclusions: Women with HIV infection, particularly those with low CD4 cell counts, shed HSV-2 from the vulva and cervix more commonly than women not infected with HIV. Most of this shedding is asymptomatic.
AB - Objective: To compare the prevalence of genital herpes simplex virus type 2 (HSV-2) shedding in human immunodeficiency virus (HIV)-seropositive women and HIV-seronegative women. Design: Cross-sectional study Setting: A major inner-city medical center. Patients: 106 women who were HIV-seropositive and HSV-2-seropositive and 70 women who were HIV-seronegative and HSV-2-seropositive were enrolled from various primary care settings. Measurements: Herpes simplex virus type 2 antibody determinations were done for all patients. Regardless of symptoms, vulvar and cervical HSV cultures were obtained from all HIV-seropositive women and from a randomly selected subgroup of HIV-seronegative women. Results: The prevalence of HSV-2 shedding was nearly four times greater Jn HIV-seropositive than in HIV-seronegative women (13.2% compared with 3.6%; P = 0.04; odds ratio, 4.1 [95% Cl, 1.0 to 27.4]) when the serum antibody for HSV-2 was present. Seventy-nine percent of viral shedding among HIV-seropositive women was asymptomatic. Overall viral shedding increased significantly as the CD4 cell count decreased. Conclusions: Women with HIV infection, particularly those with low CD4 cell counts, shed HSV-2 from the vulva and cervix more commonly than women not infected with HIV. Most of this shedding is asymptomatic.
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U2 - 10.7326/0003-4819-123-11-199512010-00006
DO - 10.7326/0003-4819-123-11-199512010-00006
M3 - Article
C2 - 7486467
AN - SCOPUS:0028799388
SN - 0003-4819
VL - 123
SP - 845
EP - 847
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 11
ER -