Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women

Michael Augenbraun, Joseph Feldman, Keith Chirgwin, Jonathan Mark Zenilman, Lorraine Clarke, Jack DeHovitz, Sheldon Landesman, Howard Minkoff

Research output: Contribution to journalArticle

Abstract

Objective: To compare the prevalence of genital herpes simplex virus type 2 (HSV-2) shedding in human immunodeficiency virus (HIV)-seropositive women and HIV-seronegative women. Design: Cross-sectional study Setting: A major inner-city medical center. Patients: 106 women who were HIV-seropositive and HSV-2-seropositive and 70 women who were HIV-seronegative and HSV-2-seropositive were enrolled from various primary care settings. Measurements: Herpes simplex virus type 2 antibody determinations were done for all patients. Regardless of symptoms, vulvar and cervical HSV cultures were obtained from all HIV-seropositive women and from a randomly selected subgroup of HIV-seronegative women. Results: The prevalence of HSV-2 shedding was nearly four times greater Jn HIV-seropositive than in HIV-seronegative women (13.2% compared with 3.6%; P = 0.04; odds ratio, 4.1 [95% Cl, 1.0 to 27.4]) when the serum antibody for HSV-2 was present. Seventy-nine percent of viral shedding among HIV-seropositive women was asymptomatic. Overall viral shedding increased significantly as the CD4 cell count decreased. Conclusions: Women with HIV infection, particularly those with low CD4 cell counts, shed HSV-2 from the vulva and cervix more commonly than women not infected with HIV. Most of this shedding is asymptomatic.

Original languageEnglish (US)
Pages (from-to)845-847
Number of pages3
JournalAnnals of Internal Medicine
Volume123
Issue number11
StatePublished - Dec 1 1995

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Herpes Genitalis
Human Herpesvirus 2
HIV
Virus Shedding
CD4 Lymphocyte Count
Vulva
Antibodies
Virus Diseases
Cervix Uteri
Primary Health Care
Cross-Sectional Studies
Odds Ratio

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Augenbraun, M., Feldman, J., Chirgwin, K., Zenilman, J. M., Clarke, L., DeHovitz, J., ... Minkoff, H. (1995). Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women. Annals of Internal Medicine, 123(11), 845-847.

Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women. / Augenbraun, Michael; Feldman, Joseph; Chirgwin, Keith; Zenilman, Jonathan Mark; Clarke, Lorraine; DeHovitz, Jack; Landesman, Sheldon; Minkoff, Howard.

In: Annals of Internal Medicine, Vol. 123, No. 11, 01.12.1995, p. 845-847.

Research output: Contribution to journalArticle

Augenbraun, M, Feldman, J, Chirgwin, K, Zenilman, JM, Clarke, L, DeHovitz, J, Landesman, S & Minkoff, H 1995, 'Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women', Annals of Internal Medicine, vol. 123, no. 11, pp. 845-847.
Augenbraun M, Feldman J, Chirgwin K, Zenilman JM, Clarke L, DeHovitz J et al. Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women. Annals of Internal Medicine. 1995 Dec 1;123(11):845-847.
Augenbraun, Michael ; Feldman, Joseph ; Chirgwin, Keith ; Zenilman, Jonathan Mark ; Clarke, Lorraine ; DeHovitz, Jack ; Landesman, Sheldon ; Minkoff, Howard. / Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women. In: Annals of Internal Medicine. 1995 ; Vol. 123, No. 11. pp. 845-847.
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