TY - JOUR
T1 - Increased Gastrointestinal Permeability and Gut Inflammation in Children with Functional Abdominal Pain and Irritable Bowel Syndrome
AU - Shulman, Robert J.
AU - Eakin, Michelle N.
AU - Czyzewski, Danita I.
AU - Jarrett, Monica
AU - Ou, Ching Nan
N1 - Funding Information:
Supported by R01 05337 to RJS, the Daffy's Foundation, P30 DK56338 which funds the Texas Medical Center Digestive Disease Center, Daffy's Foundation, and the USDA/ARS under Cooperative Agreement No. 6250-51000-043. This work is a publication of the USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, TX. The contents of this publication do not necessarily reflect the views or policies of the USDA, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
PY - 2008/11
Y1 - 2008/11
N2 - Objectives: To determine gastrointestinal (GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain symptoms and stooling. Study design: GI permeability and fecal calprotectin concentration were measured. Children kept a 2-week diary of pain episodes and stooling pattern. Results: Proximal GI permeability was greater in the FAP/IBS group (n = 93) compared with control subjects (n = 52) (0.59 ± 0.50 vs 0.36 ± 0.26, respectively; mean ± SD; P < .001) as was colonic permeability (1.01 ± 0.67 vs 0.81 ± 0.43, respectively; P < .05). Gastric and small intestinal permeability were similar. Fecal calprotectin concentration was greater in children with FAP/IBS compared with control children (65.5 ± 75.4 μg/g stool vs 43.2 ± 39.4, respectively; P < .01). Fecal calprotectin concentration correlated with pain interference with activities (P = .01, r2 = 0.36). There was no correlation between GI permeability and pain related symptoms. Neither permeability nor fecal calprotectin correlated with stool form. Conclusions: Children with FAP/IBS have evidence of increased GI permeability and low-grade GI inflammation, with the latter relating to the degree to which pain interferes with activities.
AB - Objectives: To determine gastrointestinal (GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain symptoms and stooling. Study design: GI permeability and fecal calprotectin concentration were measured. Children kept a 2-week diary of pain episodes and stooling pattern. Results: Proximal GI permeability was greater in the FAP/IBS group (n = 93) compared with control subjects (n = 52) (0.59 ± 0.50 vs 0.36 ± 0.26, respectively; mean ± SD; P < .001) as was colonic permeability (1.01 ± 0.67 vs 0.81 ± 0.43, respectively; P < .05). Gastric and small intestinal permeability were similar. Fecal calprotectin concentration was greater in children with FAP/IBS compared with control children (65.5 ± 75.4 μg/g stool vs 43.2 ± 39.4, respectively; P < .01). Fecal calprotectin concentration correlated with pain interference with activities (P = .01, r2 = 0.36). There was no correlation between GI permeability and pain related symptoms. Neither permeability nor fecal calprotectin correlated with stool form. Conclusions: Children with FAP/IBS have evidence of increased GI permeability and low-grade GI inflammation, with the latter relating to the degree to which pain interferes with activities.
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U2 - 10.1016/j.jpeds.2008.04.062
DO - 10.1016/j.jpeds.2008.04.062
M3 - Article
C2 - 18538790
AN - SCOPUS:55549142198
SN - 0022-3476
VL - 153
SP - 646
EP - 650
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -