Increased frequency of the tumor necrosis factor-α-308 A allele in adults with human immunodeficiency virus dementia

Michael W. Quasney, Qing Zhang, Susie Sargent, Margaret Mynatt, Jonathan Glass, Justin Charles McArthur

Research output: Contribution to journalArticle

Abstract

Genetic polymorphisms in the regulatory regions of various cytokine genes influence the amount of cytokine produced in response to inflammatory stimuli. To determine whether such polymorphisms might play a role in human immunodeficiency virus (HIV) dementia, a disease process in which tumor necrosis factor (TNF)-α is believed to play a role, we analyzed HIV-infected adults with and without dementia and control populations for a polymorphic site located in the promoter region of the gene coding for TNF-α. The presence of the A allele at the TNF-α-308 site was overrepresented among adults with HIV dementia compared to those without dementia (0.28 vs 0.07; OR 5.5; 95% CI 1.8-17.0) and a healthy control population (0.28 vs 0.11). The increased frequency of the A allele in HIV-infected adults with dementia suggests that this locus may play a role in the pathophysiology of dementia and suggests a genetic predisposition for the development of HIV dementia.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalAnnals of Neurology
Volume50
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

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Dementia
Tumor Necrosis Factor-alpha
Alleles
HIV
Cytokines
Nucleic Acid Regulatory Sequences
Genetic Polymorphisms
Genetic Predisposition to Disease
Genetic Promoter Regions
Gene Frequency
Population
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Increased frequency of the tumor necrosis factor-α-308 A allele in adults with human immunodeficiency virus dementia. / Quasney, Michael W.; Zhang, Qing; Sargent, Susie; Mynatt, Margaret; Glass, Jonathan; McArthur, Justin Charles.

In: Annals of Neurology, Vol. 50, No. 2, 2001, p. 157-162.

Research output: Contribution to journalArticle

Quasney, Michael W. ; Zhang, Qing ; Sargent, Susie ; Mynatt, Margaret ; Glass, Jonathan ; McArthur, Justin Charles. / Increased frequency of the tumor necrosis factor-α-308 A allele in adults with human immunodeficiency virus dementia. In: Annals of Neurology. 2001 ; Vol. 50, No. 2. pp. 157-162.
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