Increased frequency of the tumor necrosis factor-α-308 A allele in adults with human immunodeficiency virus dementia

Michael W. Quasney, Qing Zhang, Susie Sargent, Margaret Mynatt, Jonathan Glass, Justin McArthur

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic polymorphisms in the regulatory regions of various cytokine genes influence the amount of cytokine produced in response to inflammatory stimuli. To determine whether such polymorphisms might play a role in human immunodeficiency virus (HIV) dementia, a disease process in which tumor necrosis factor (TNF)-α is believed to play a role, we analyzed HIV-infected adults with and without dementia and control populations for a polymorphic site located in the promoter region of the gene coding for TNF-α. The presence of the A allele at the TNF-α-308 site was overrepresented among adults with HIV dementia compared to those without dementia (0.28 vs 0.07; OR 5.5; 95% CI 1.8-17.0) and a healthy control population (0.28 vs 0.11). The increased frequency of the A allele in HIV-infected adults with dementia suggests that this locus may play a role in the pathophysiology of dementia and suggests a genetic predisposition for the development of HIV dementia.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalAnnals of neurology
Volume50
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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