Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus

F. C. Arnett, Robert G Hamilton, M. G. Roebber, J. B. Harley, M. Reichlin

Research output: Contribution to journalArticle

Abstract

Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.

Original languageEnglish (US)
Pages (from-to)1773-1776
Number of pages4
JournalJournal of Rheumatology
Volume15
Issue number12
StatePublished - 1988
Externally publishedYes

Fingerprint

Counterimmunoelectrophoresis
Systemic Lupus Erythematosus
Autoantibodies
Enzyme-Linked Immunosorbent Assay
hydroquinone
SS-A antibodies

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus. / Arnett, F. C.; Hamilton, Robert G; Roebber, M. G.; Harley, J. B.; Reichlin, M.

In: Journal of Rheumatology, Vol. 15, No. 12, 1988, p. 1773-1776.

Research output: Contribution to journalArticle

@article{cdda98704ee4432fbb5bb900768c7112,
title = "Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus",
abstract = "Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25{\%}) than whites (10{\%}) (p = 0.02), as did anti-nRNP (40{\%} versus 23{\%}; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47{\%} of blacks and 24{\%} of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52{\%} of blacks versus 26{\%} of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.",
author = "Arnett, {F. C.} and Hamilton, {Robert G} and Roebber, {M. G.} and Harley, {J. B.} and M. Reichlin",
year = "1988",
language = "English (US)",
volume = "15",
pages = "1773--1776",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "12",

}

TY - JOUR

T1 - Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus

AU - Arnett, F. C.

AU - Hamilton, Robert G

AU - Roebber, M. G.

AU - Harley, J. B.

AU - Reichlin, M.

PY - 1988

Y1 - 1988

N2 - Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.

AB - Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.

UR - http://www.scopus.com/inward/record.url?scp=0024206349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024206349&partnerID=8YFLogxK

M3 - Article

C2 - 3230562

AN - SCOPUS:0024206349

VL - 15

SP - 1773

EP - 1776

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 12

ER -