Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus

F. C. Arnett, R. G. Hamilton, M. G. Roebber, J. B. Harley, M. Reichlin

Research output: Contribution to journalArticlepeer-review

Abstract

Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.

Original languageEnglish (US)
Pages (from-to)1773-1776
Number of pages4
JournalJournal of Rheumatology
Volume15
Issue number12
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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