Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [11C]FLB 457 PET study

Ji Hyun Ko, Alain Ptito, Oury Monchi, Sang Soo Cho, Thilo Van Eimeren, Giovanna Pellecchia, Benedicte Ballanger, Pablo Rusjan, Sylvain Houle, Antonio P. Strafella

Research output: Contribution to journalArticlepeer-review

Abstract

There is clear evidence that the prefrontal cortex is strongly involved in executive processes and that dopamine can influence performance on working memory tasks. Although, some studies have emphasized the role of striatal dopamine in executive functions, the role played by prefrontal dopamine during executive tasks is unknown. In order to investigate cortical dopamine transmission during executive function, we used D2-dopamine receptor ligand [11C]FLB 457 PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). During the retrieval with shift task of the MCST, the subjects had to match each test card to one of the reference cards based on a classification rule (color, shape or number) determined by comparing the previously viewed cue card and the current test card. A reduction in [11C]FLB 457 binding potential in the right dorsal anterior cingulate cortex (ACC) was observed when subjects performed the active task compared to the control task. These findings may suggest that right dorsal ACC dopamine neurotransmission increases significantly during the performance of certain executive processes, e.g., conflict monitoring, in keeping with previous evidence from fMRI studies showing ACC activation during similar tasks. These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalNeuroImage
Volume46
Issue number2
DOIs
StatePublished - Jun 2009

Keywords

  • Anterior cingulate cortex
  • Conflict monitoring
  • Dopamine
  • Executive function
  • FLB 457
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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