TY - JOUR
T1 - Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task
T2 - A [11C]FLB 457 PET study
AU - Ko, Ji Hyun
AU - Ptito, Alain
AU - Monchi, Oury
AU - Cho, Sang Soo
AU - Van Eimeren, Thilo
AU - Pellecchia, Giovanna
AU - Ballanger, Benedicte
AU - Rusjan, Pablo
AU - Houle, Sylvain
AU - Strafella, Antonio P.
N1 - Funding Information:
We wish to thank all the staff of the CAMH-PET imaging center for their assistance in carrying out the studies. This work was funded by the Canadian Institutes of Health Research to APS (MOP-64423). APS is supported by the CIHR New Investigator Research Award.
PY - 2009/6
Y1 - 2009/6
N2 - There is clear evidence that the prefrontal cortex is strongly involved in executive processes and that dopamine can influence performance on working memory tasks. Although, some studies have emphasized the role of striatal dopamine in executive functions, the role played by prefrontal dopamine during executive tasks is unknown. In order to investigate cortical dopamine transmission during executive function, we used D2-dopamine receptor ligand [11C]FLB 457 PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). During the retrieval with shift task of the MCST, the subjects had to match each test card to one of the reference cards based on a classification rule (color, shape or number) determined by comparing the previously viewed cue card and the current test card. A reduction in [11C]FLB 457 binding potential in the right dorsal anterior cingulate cortex (ACC) was observed when subjects performed the active task compared to the control task. These findings may suggest that right dorsal ACC dopamine neurotransmission increases significantly during the performance of certain executive processes, e.g., conflict monitoring, in keeping with previous evidence from fMRI studies showing ACC activation during similar tasks. These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia.
AB - There is clear evidence that the prefrontal cortex is strongly involved in executive processes and that dopamine can influence performance on working memory tasks. Although, some studies have emphasized the role of striatal dopamine in executive functions, the role played by prefrontal dopamine during executive tasks is unknown. In order to investigate cortical dopamine transmission during executive function, we used D2-dopamine receptor ligand [11C]FLB 457 PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). During the retrieval with shift task of the MCST, the subjects had to match each test card to one of the reference cards based on a classification rule (color, shape or number) determined by comparing the previously viewed cue card and the current test card. A reduction in [11C]FLB 457 binding potential in the right dorsal anterior cingulate cortex (ACC) was observed when subjects performed the active task compared to the control task. These findings may suggest that right dorsal ACC dopamine neurotransmission increases significantly during the performance of certain executive processes, e.g., conflict monitoring, in keeping with previous evidence from fMRI studies showing ACC activation during similar tasks. These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia.
KW - Anterior cingulate cortex
KW - Conflict monitoring
KW - Dopamine
KW - Executive function
KW - FLB 457
KW - Positron emission tomography
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U2 - 10.1016/j.neuroimage.2009.02.031
DO - 10.1016/j.neuroimage.2009.02.031
M3 - Article
C2 - 19264140
AN - SCOPUS:64049084268
SN - 1053-8119
VL - 46
SP - 516
EP - 521
JO - NeuroImage
JF - NeuroImage
IS - 2
ER -