Increased CSF IgM in multiple sclerosis

A. C. Williams; E. S. Mingioli; H. F. McFarland; W. W. Tourtellotte; D. E. McFarlin

Increased CSF IgM in multiple sclerosis

A. C. Williams, E. S. Mingioli, H. F. McFarland, W. W. Tourtellotte, D. E. McFarlin

Research output: Contribution to journal › Article › peer-review

Abstract

CSF IgM levels have been measured by radioimmunoassay in 56 patients with MS, 62 patients with other neurologic diseases, and 31 normal controls. Forty-eight percent of the patients with MS had a raised CSF IgM level compared with 5 percent of the patients with other diseases. The IgM level did not correlate with the IgG level. Forty percent of the MS patients with normal IgG levels had high IgM levels. No relationship was found between the CSF IgM level and length or severity of the MS, relapses, or steroid therapy. Attempts to identify the IgM as being anti-measles were unsuccessful.

Original language	English (US)
Pages (from-to)	996-998
Number of pages	3
Journal	Neurology
Volume	28
Issue number	10
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology
General Neuroscience

Cite this

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title = "Increased CSF IgM in multiple sclerosis",

abstract = "CSF IgM levels have been measured by radioimmunoassay in 56 patients with MS, 62 patients with other neurologic diseases, and 31 normal controls. Forty-eight percent of the patients with MS had a raised CSF IgM level compared with 5 percent of the patients with other diseases. The IgM level did not correlate with the IgG level. Forty percent of the MS patients with normal IgG levels had high IgM levels. No relationship was found between the CSF IgM level and length or severity of the MS, relapses, or steroid therapy. Attempts to identify the IgM as being anti-measles were unsuccessful.",

author = "Williams, {A. C.} and Mingioli, {E. S.} and McFarland, {H. F.} and Tourtellotte, {W. W.} and McFarlin, {D. E.}",

year = "1978",

language = "English (US)",

volume = "28",

pages = "996--998",

journal = "Neurology",

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TY - JOUR

T1 - Increased CSF IgM in multiple sclerosis

AU - Williams, A. C.

AU - Mingioli, E. S.

AU - McFarland, H. F.

AU - Tourtellotte, W. W.

AU - McFarlin, D. E.

PY - 1978

Y1 - 1978

N2 - CSF IgM levels have been measured by radioimmunoassay in 56 patients with MS, 62 patients with other neurologic diseases, and 31 normal controls. Forty-eight percent of the patients with MS had a raised CSF IgM level compared with 5 percent of the patients with other diseases. The IgM level did not correlate with the IgG level. Forty percent of the MS patients with normal IgG levels had high IgM levels. No relationship was found between the CSF IgM level and length or severity of the MS, relapses, or steroid therapy. Attempts to identify the IgM as being anti-measles were unsuccessful.

AB - CSF IgM levels have been measured by radioimmunoassay in 56 patients with MS, 62 patients with other neurologic diseases, and 31 normal controls. Forty-eight percent of the patients with MS had a raised CSF IgM level compared with 5 percent of the patients with other diseases. The IgM level did not correlate with the IgG level. Forty percent of the MS patients with normal IgG levels had high IgM levels. No relationship was found between the CSF IgM level and length or severity of the MS, relapses, or steroid therapy. Attempts to identify the IgM as being anti-measles were unsuccessful.

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M3 - Article

AN - SCOPUS:0017895777

SN - 0028-3878

VL - 28

SP - 996

EP - 998

JO - Neurology

JF - Neurology

IS - 10

ER -

Increased CSF IgM in multiple sclerosis

Abstract

ASJC Scopus subject areas

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