Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome

R. P. Allen, E. Mignot, B. Ripley, S. Nishino, C. J. Earley

Research output: Contribution to journalArticlepeer-review


Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.

Original languageEnglish (US)
Pages (from-to)639-641
Number of pages3
Issue number4
StatePublished - Aug 27 2002
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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