Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome

R. P. Allen; E. Mignot; B. Ripley; S. Nishino; C. J. Earley

doi:10.1212/WNL.59.4.639

Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome

R. P. Allen, E. Mignot, B. Ripley, S. Nishino, C. J. Earley

Research output: Contribution to journal › Article › peer-review

Abstract

Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.

Original language	English (US)
Pages (from-to)	639-641
Number of pages	3
Journal	Neurology
Volume	59
Issue number	4
DOIs	https://doi.org/10.1212/WNL.59.4.639
State	Published - Aug 27 2002
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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