Increased coronary artery blood flow with aortomyoplasty in chronic heart failure

Brian L. Cmolik, Dirk R. Thompson, J. Timothy Sherwood, Alexander S. Geha, David T. George

Research output: Contribution to journalArticle

Abstract

Background. We hypothesized that diastolic counter-pulsation using aortomyoplasty will increase coronary blood flow. Methods. In dogs (n = 6, 20 to 25 kg), the left latissimus dorsi muscle was isolated, wrapped around the descending thoracic aorta, and conditioned by chronic electrical stimulation. Heart failure was induced by rapid ventricular pacing. In a terminal study, left ventricular and aortic pressures, and blood flow in the left anterior descending coronary artery and descending aorta were measured. The endocardial-viability ratio was calculated. Results. Aortomyoplasty increased mean diastolic aortic pressure (70 ± 5 to 75 ± 5 mm Hg, p <0.05) and reduced peak left ventricular pressure, (86 ± 4 to 84 ± 4 mm Hg, p <0.05), leading to a 16% increase in endocardial-viability ratio (1.29 ± 0.05 to 1.49 ± 0.05, p <0.05). Coronary blood flow was increased by 15% (8.2 ± 1.5 to 9.4 ± 1.6 mL/min, p <0.05). During muscle contraction, 2.7 ± 0.5 mL was ejected from the wrapped aortic segment. Conclusions. These data demonstrate that aortomyoplasty provides successful diastolic counterpulsation after muscle conditioning and heart failure.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalAnnals of Thoracic Surgery
Volume71
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Thoracic Aorta
Coronary Vessels
Heart Failure
Ventricular Pressure
Arterial Pressure
Counterpulsation
Muscles
Superficial Back Muscles
Muscle Contraction
Electric Stimulation
Dogs
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Cmolik, B. L., Thompson, D. R., Sherwood, J. T., Geha, A. S., & George, D. T. (2001). Increased coronary artery blood flow with aortomyoplasty in chronic heart failure. Annals of Thoracic Surgery, 71(1), 284-289. https://doi.org/10.1016/S0003-4975(00)02242-6

Increased coronary artery blood flow with aortomyoplasty in chronic heart failure. / Cmolik, Brian L.; Thompson, Dirk R.; Sherwood, J. Timothy; Geha, Alexander S.; George, David T.

In: Annals of Thoracic Surgery, Vol. 71, No. 1, 2001, p. 284-289.

Research output: Contribution to journalArticle

Cmolik, BL, Thompson, DR, Sherwood, JT, Geha, AS & George, DT 2001, 'Increased coronary artery blood flow with aortomyoplasty in chronic heart failure', Annals of Thoracic Surgery, vol. 71, no. 1, pp. 284-289. https://doi.org/10.1016/S0003-4975(00)02242-6
Cmolik, Brian L. ; Thompson, Dirk R. ; Sherwood, J. Timothy ; Geha, Alexander S. ; George, David T. / Increased coronary artery blood flow with aortomyoplasty in chronic heart failure. In: Annals of Thoracic Surgery. 2001 ; Vol. 71, No. 1. pp. 284-289.
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