TY - JOUR
T1 - Increased coronary artery blood flow with aortomyoplasty in chronic heart failure
AU - Cmolik, Brian L.
AU - Thompson, Dirk R.
AU - Sherwood, J. Timothy
AU - Geha, Alexander S.
AU - George, David T.
N1 - Funding Information:
We thank Mark E. Dunlap, MD, for his assistance with the rapid-pacing heart failure model. We acknowledge the outstanding support of Lisa Cardon, who did the echocardiographic studies for this project, and Sherrie Lawrence, for her help with the illustrations. This work was supported by a grant from the Northeast Ohio Affiliate of the American Heart Association.
PY - 2001
Y1 - 2001
N2 - Background. We hypothesized that diastolic counter-pulsation using aortomyoplasty will increase coronary blood flow. Methods. In dogs (n = 6, 20 to 25 kg), the left latissimus dorsi muscle was isolated, wrapped around the descending thoracic aorta, and conditioned by chronic electrical stimulation. Heart failure was induced by rapid ventricular pacing. In a terminal study, left ventricular and aortic pressures, and blood flow in the left anterior descending coronary artery and descending aorta were measured. The endocardial-viability ratio was calculated. Results. Aortomyoplasty increased mean diastolic aortic pressure (70 ± 5 to 75 ± 5 mm Hg, p < 0.05) and reduced peak left ventricular pressure, (86 ± 4 to 84 ± 4 mm Hg, p < 0.05), leading to a 16% increase in endocardial-viability ratio (1.29 ± 0.05 to 1.49 ± 0.05, p < 0.05). Coronary blood flow was increased by 15% (8.2 ± 1.5 to 9.4 ± 1.6 mL/min, p < 0.05). During muscle contraction, 2.7 ± 0.5 mL was ejected from the wrapped aortic segment. Conclusions. These data demonstrate that aortomyoplasty provides successful diastolic counterpulsation after muscle conditioning and heart failure.
AB - Background. We hypothesized that diastolic counter-pulsation using aortomyoplasty will increase coronary blood flow. Methods. In dogs (n = 6, 20 to 25 kg), the left latissimus dorsi muscle was isolated, wrapped around the descending thoracic aorta, and conditioned by chronic electrical stimulation. Heart failure was induced by rapid ventricular pacing. In a terminal study, left ventricular and aortic pressures, and blood flow in the left anterior descending coronary artery and descending aorta were measured. The endocardial-viability ratio was calculated. Results. Aortomyoplasty increased mean diastolic aortic pressure (70 ± 5 to 75 ± 5 mm Hg, p < 0.05) and reduced peak left ventricular pressure, (86 ± 4 to 84 ± 4 mm Hg, p < 0.05), leading to a 16% increase in endocardial-viability ratio (1.29 ± 0.05 to 1.49 ± 0.05, p < 0.05). Coronary blood flow was increased by 15% (8.2 ± 1.5 to 9.4 ± 1.6 mL/min, p < 0.05). During muscle contraction, 2.7 ± 0.5 mL was ejected from the wrapped aortic segment. Conclusions. These data demonstrate that aortomyoplasty provides successful diastolic counterpulsation after muscle conditioning and heart failure.
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U2 - 10.1016/S0003-4975(00)02242-6
DO - 10.1016/S0003-4975(00)02242-6
M3 - Article
C2 - 11216762
AN - SCOPUS:0035137010
SN - 0003-4975
VL - 71
SP - 284
EP - 289
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 1
ER -