Increased circulating levels of bromocriptine after vaginal compared with oral administration

E. Katz, B. E. Weiss, A. Hassell, H. F. Schran, E. Y. Adashi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the circulating levels of bromocriptine after oral and vaginal administration of the drug. Design: Experimental. Participants: Seven ovulatory female volunteers and one hyperprolactinemic patient. Interventions: Ovulatory volunteers were randomized to receive either oral or vaginal bromocriptine (2.5 mg). In a second session, the subjects were crossed-over to bromocriptine by the alternate route. An additional hyperprolactinemic patient received vaginal bromocriptine only. Main Outcome Measure: Serum bromocriptine and prolactin (PRL) levels were measured hourly for 12 hours in the normal volunteers and for 10 hours in the hyperprolactinemic patient. Results: Circulating bromocriptine levels were significantly higher after vaginal bromocriptine after the 7th hour (P < 0.05). The reduction in serum PRL was significantly greater after oral administration between 2 and 6 hours. Conclusions: Vaginally administered bromocriptine may result in a reduction in the overall dose required, thereby improving compliance without compromising therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)882-884
Number of pages3
JournalFertility and sterility
Volume55
Issue number5
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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