Increased chromosomal radiosensitivity in patients undergoing radioimmunoglobulin therapy

Shuquin Xiao, David Jacobson-Kram, Steven Piantadosi, Jerry R. Williams

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Lymphocytes from individual patients undergoing radiolabeled immmunoglobulin therapy have been examined both for chromosome aberrations expressed immediately upon explant, or for chromosome aberrations induced by a subsequent challenge of γ-rays after PHA-stimulated proliferation. Despite interpatient variation, there is strong correlation between levels of chromosome aberrations observed in the initial mitosis after mitogenic stimulation and levels induced by a challenging dose of radiation in replicate cultures after several cell cycles of growth. These data indicated that even after proliferation, human lymphocytes retain a memory of in vivo exposure to ionizing radiation that can be observed by challenge with a clastogenic agent. This persistent hypersensitivity occurs at high frequency, suggesting that it may be related to initial steps in multistage carcinogenesis.

    Original languageEnglish (US)
    Pages (from-to)39-45
    Number of pages7
    JournalMutation Research Letters
    Volume227
    Issue number1
    DOIs
    StatePublished - Sep 1989

    Keywords

    • Chromosomal radiosensitivity
    • Immunoglobulin therapy, lymphocytes
    • Radioimmunoglobulin therapy

    ASJC Scopus subject areas

    • Medicine(all)

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