Lymphocytes from individual patients undergoing radiolabeled immmunoglobulin therapy have been examined both for chromosome aberrations expressed immediately upon explant, or for chromosome aberrations induced by a subsequent challenge of γ-rays after PHA-stimulated proliferation. Despite interpatient variation, there is strong correlation between levels of chromosome aberrations observed in the initial mitosis after mitogenic stimulation and levels induced by a challenging dose of radiation in replicate cultures after several cell cycles of growth. These data indicated that even after proliferation, human lymphocytes retain a memory of in vivo exposure to ionizing radiation that can be observed by challenge with a clastogenic agent. This persistent hypersensitivity occurs at high frequency, suggesting that it may be related to initial steps in multistage carcinogenesis.
- Chromosomal radiosensitivity
- Immunoglobulin therapy, lymphocytes
- Radioimmunoglobulin therapy
ASJC Scopus subject areas