Increased body weight in mice lacking mu-opioid receptors

Wenhua Han, Harumi Hata, Hiroki Imbe, Qing Rong Liu, Yukio Takamatsu, Miwako Koizumi, Niall P. Murphy, Emiko Senba, George R. Uhl, Ichiro Sora, Kazutaka Ikeda

Research output: Contribution to journalArticlepeer-review

Abstract

Opioids have been suggested to affect feeding behaviour. To clarify the role of μ-opioid receptors in feeding, we measured several parameters relating to food intake in μ-opioid receptor knockout mice. Here, we show that the knockout mice had increased body weight in adulthood, although the intake amount of standard food was similar between the wild-type and knockout littermates. Serum markers for energy homeostasis were not significantly altered in the knockout mice. Hypothalamic neuropeptide Y mRNA, however, was higher in knockouts than in wild-type mice. Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult μ-opioid receptor knockout mice.

Original languageEnglish (US)
Pages (from-to)941-944
Number of pages4
JournalNeuroReport
Volume17
Issue number9
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • μ-opioid receptor
  • Body weight
  • Food intake
  • Knockout
  • Neuropeptide Y

ASJC Scopus subject areas

  • Neuroscience(all)

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