Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with schistosoma mansoni

Jerrold J. Ellner, David J. Tweardy, Gamal S. Osman, Carla Wilson, Aziz El Kholy, Ross E. Rocklin

Research output: Contribution to journalArticlepeer-review

Abstract

Fifteen Egyptian subjects infected with Schistosoma mansoni were evaluated parasitologically, clinically, and immunologically; treated with praziquantel; and reevaluated nine months later. Fecal egg counts were 97% lower after therapy; seven subjects no longer excreted eggs, as determined by Kato thick smears. Optimal [3H]thymidine incorporation induced by soluble adult worm antigenic preparation (SWAP) in peripheral blood mononuclear cells (PBMCs) increased significantly, from 4, 041 ± 434 (mean change in cpm ± SE) before treatment to 11, 232 ± 3, 414 after treatment (P

Original languageEnglish (US)
Pages (from-to)320-324
Number of pages5
JournalJournal of Infectious Diseases
Volume151
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health
  • Immunology

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