Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with schistosoma mansoni

Jerrold J. Ellner; David J. Tweardy; Gamal S. Osman; Carla Wilson; Aziz El Kholy; Ross E. Rocklin

doi:10.1093/infdis/151.2.320

Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with schistosoma mansoni

Jerrold J. Ellner, David J. Tweardy, Gamal S. Osman, Carla Wilson, Aziz El Kholy, Ross E. Rocklin

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Fifteen Egyptian subjects infected with Schistosoma mansoni were evaluated parasitologically, clinically, and immunologically; treated with praziquantel; and reevaluated nine months later. Fecal egg counts were 97% lower after therapy; seven subjects no longer excreted eggs, as determined by Kato thick smears. Optimal [³H]thymidine incorporation induced by soluble adult worm antigenic preparation (SWAP) in peripheral blood mononuclear cells (PBMCs) increased significantly, from 4, 041 ± 434 (mean change in cpm ± SE) before treatment to 11, 232 ± 3, 414 after treatment (P

Original language	English (US)
Pages (from-to)	320-324
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	151
Issue number	2
DOIs	https://doi.org/10.1093/infdis/151.2.320
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy
Public Health, Environmental and Occupational Health
Immunology

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10.1093/infdis/151.2.320

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title = "Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with schistosoma mansoni",

abstract = "Fifteen Egyptian subjects infected with Schistosoma mansoni were evaluated parasitologically, clinically, and immunologically; treated with praziquantel; and reevaluated nine months later. Fecal egg counts were 97% lower after therapy; seven subjects no longer excreted eggs, as determined by Kato thick smears. Optimal [3H]thymidine incorporation induced by soluble adult worm antigenic preparation (SWAP) in peripheral blood mononuclear cells (PBMCs) increased significantly, from 4, 041 ± 434 (mean change in cpm ± SE) before treatment to 11, 232 ± 3, 414 after treatment (P ",

author = "Ellner, {Jerrold J.} and Tweardy, {David J.} and Osman, {Gamal S.} and Carla Wilson and {El Kholy}, Aziz and Rocklin, {Ross E.}",

year = "1985",

doi = "10.1093/infdis/151.2.320",

language = "English (US)",

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pages = "320--324",

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T1 - Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with schistosoma mansoni

AU - Ellner, Jerrold J.

AU - Tweardy, David J.

AU - Osman, Gamal S.

AU - Wilson, Carla

AU - El Kholy, Aziz

AU - Rocklin, Ross E.

PY - 1985

Y1 - 1985

N2 - Fifteen Egyptian subjects infected with Schistosoma mansoni were evaluated parasitologically, clinically, and immunologically; treated with praziquantel; and reevaluated nine months later. Fecal egg counts were 97% lower after therapy; seven subjects no longer excreted eggs, as determined by Kato thick smears. Optimal [3H]thymidine incorporation induced by soluble adult worm antigenic preparation (SWAP) in peripheral blood mononuclear cells (PBMCs) increased significantly, from 4, 041 ± 434 (mean change in cpm ± SE) before treatment to 11, 232 ± 3, 414 after treatment (P

AB - Fifteen Egyptian subjects infected with Schistosoma mansoni were evaluated parasitologically, clinically, and immunologically; treated with praziquantel; and reevaluated nine months later. Fecal egg counts were 97% lower after therapy; seven subjects no longer excreted eggs, as determined by Kato thick smears. Optimal [3H]thymidine incorporation induced by soluble adult worm antigenic preparation (SWAP) in peripheral blood mononuclear cells (PBMCs) increased significantly, from 4, 041 ± 434 (mean change in cpm ± SE) before treatment to 11, 232 ± 3, 414 after treatment (P

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Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with schistosoma mansoni

Abstract

ASJC Scopus subject areas

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