Increased biosynthesis of specific glycoconjugates in rat cornea epithelium following treatment with vitamin A

J. R. Hassell, D. A. Newsome, L. M. De Luca

Research output: Contribution to journalArticlepeer-review

Abstract

The biosynthesis of corneal epithelial proteins and glycoconjugates and their response to vitamin A were measured in vitamin A-deficient and normal rats. The synthesis of specific high-molecular-weight epithelial glycoconjugates was directly related to the levels of vitamin A administered. Protein synthesis, however, remained unaltered. Since vitamin A is known to reverse the keratinization process, the vitamin A-regulated high-molecular-weight glycoconjugates may play a role in modulating the expression of the keratinizing phenotype.

Original languageEnglish (US)
Pages (from-to)642-647
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number6
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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