Increased beat-to-beat QT variability in patients with congestive cardiac failure

D. S. Raghunandan, Nagaraj Desai, Mallika Mallavarapu, Ronald D. Berger, Vikram K. Yeragani

Research output: Contribution to journalArticle

Abstract

Background: QT interval on the surface electrocardiogram reflects the time for repolarization of myocardium. Prolongation of rate-corrected QT interval, QTc is strongly associated with sudden cardiac death. Recent studies using novel techniques on beat-to-beat QT interval variability have shown that an increase in QT interval variability is associated with increased sympathetic activity and is a predictor of sudden cardiac death. We studied QT variability in patients with congestive cardiac failure, as it is associated with an increase in cardiac sympathetic activity and also sudden death. Methods and Results: We compared beat-to-beat heart rate and QT interval data in 23 patients with congestive cardiac failure and 19 age-matched normal controls. The electrocardiographic data were acquired in lead II configuration at a sampling rate of 1000 Hz. Heart rate variability was found to be significantly lower while QT variability measures were significantly higher in patients compared to controls. QTvi (a common log ratio of QT variability normalized for mean QT interval squared divided by heart rate variability normalized for mean heart rate squared) was also significantly higher in patients compared to controls. Clinical improvement in some of these patients is associated with a decrease in QTvi, due mainly to an increase in cardiac vagal function. Conclusions: Our results suggest a decrease in cardiac vagal and an increase in cardiac sympathetic functions in patients with congestive cardiac failure. QTvi may prove to be a useful surrogate end point to evaluate treatment effect in these patients.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalIndian Heart Journal
Volume57
Issue number2
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Congestive heart failure
  • Heart rate variability
  • QT Variability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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