Increased apoptosis in metastatic human colonic adenocarcinomas

Paula M. Termuhlen; Bridget M. Sweeney-Gotsch; Russell S. Berman; Lee M. Ellis; Corazon Bucana; Yu Shen; Karen R. Cleary; David J. McConkey

doi:10.4161/cbt.1.1.43

Increased apoptosis in metastatic human colonic adenocarcinomas

Paula M. Termuhlen, Bridget M. Sweeney-Gotsch, Russell S. Berman, Lee M. Ellis, Corazon Bucana, Yu Shen, Karen R. Cleary, David J. McConkey

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Recent work suggests that apoptosis is disrupted during the progression of many solid tumors. Isogenic metastatic colon adenocarcinoma cells displayed significantly higher levels of staurosporine-induced apoptosis compared to their nonmetastatic counterparts in vitro. In addition, analysis of 15 matched primary tumors and liver metastases demonstrated that the levels of apoptosis were significantly higher in the metastases, and this increased cell death was associated with significantly lower levels of Bcl-2 protein expression. Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli.

Original language	English (US)
Pages (from-to)	58-63
Number of pages	6
Journal	Cancer Biology and Therapy
Volume	1
Issue number	1
DOIs	https://doi.org/10.4161/cbt.1.1.43
State	Published - Jan 2002
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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title = "Increased apoptosis in metastatic human colonic adenocarcinomas",

abstract = "Recent work suggests that apoptosis is disrupted during the progression of many solid tumors. Isogenic metastatic colon adenocarcinoma cells displayed significantly higher levels of staurosporine-induced apoptosis compared to their nonmetastatic counterparts in vitro. In addition, analysis of 15 matched primary tumors and liver metastases demonstrated that the levels of apoptosis were significantly higher in the metastases, and this increased cell death was associated with significantly lower levels of Bcl-2 protein expression. Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli.",

author = "Termuhlen, {Paula M.} and Sweeney-Gotsch, {Bridget M.} and Berman, {Russell S.} and Ellis, {Lee M.} and Corazon Bucana and Yu Shen and Cleary, {Karen R.} and McConkey, {David J.}",

year = "2002",

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T1 - Increased apoptosis in metastatic human colonic adenocarcinomas

AU - Termuhlen, Paula M.

AU - Sweeney-Gotsch, Bridget M.

AU - Berman, Russell S.

AU - Ellis, Lee M.

AU - Bucana, Corazon

AU - Shen, Yu

AU - Cleary, Karen R.

AU - McConkey, David J.

PY - 2002/1

Y1 - 2002/1

N2 - Recent work suggests that apoptosis is disrupted during the progression of many solid tumors. Isogenic metastatic colon adenocarcinoma cells displayed significantly higher levels of staurosporine-induced apoptosis compared to their nonmetastatic counterparts in vitro. In addition, analysis of 15 matched primary tumors and liver metastases demonstrated that the levels of apoptosis were significantly higher in the metastases, and this increased cell death was associated with significantly lower levels of Bcl-2 protein expression. Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli.

AB - Recent work suggests that apoptosis is disrupted during the progression of many solid tumors. Isogenic metastatic colon adenocarcinoma cells displayed significantly higher levels of staurosporine-induced apoptosis compared to their nonmetastatic counterparts in vitro. In addition, analysis of 15 matched primary tumors and liver metastases demonstrated that the levels of apoptosis were significantly higher in the metastases, and this increased cell death was associated with significantly lower levels of Bcl-2 protein expression. Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli.

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Increased apoptosis in metastatic human colonic adenocarcinomas

Abstract

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