Increased adherence of fluconazole-resistant isolates of Candida species to explanted esophageal mucosa

C. A. Lyman, K. F. Garrett, J. Peter, C. Gonzalez, T. J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

The adherence of fluconazole-resistant and fluconazole-susceptible isolates of Candida albicans to explanted rabbit esophageal mucosa was examined in vivo. Among six Candida albicans isolates collected from HIV-infected patients, three fluconazole-resistant (MIC > 64 μg/ml) isolates attached more avidly than three fluconazole-susceptible strains (MIC ≤ 0.5 μg/ml) to esophageal mucosa (P ≤ 0.05). When three strains each of six different Candida spp. were compared, the more inherently fluconazole-resistant isolates adhered more avidly in the following order: Candida glabrata > Candida krusei > Candida albicans fluconazole-sensitive > Candida tropicalis > Candida parapsilosis. Nonetheless, fluconazole-resistant Candida albicans demonstrated the greatest degree of adherence in comparison to all fluconazole-susceptible Candida albicans (P < 0.001) and to all Candida spp. tested (P < 0.001). Thus, the refractoriness of esophageal candidiasis in patients infected with fluconazole-resistant isolates may be related to both in vitro drug resistance and increased mucosal adherence.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume18
Issue number3
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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