Increased 30-day mortality associated with carbapenem-resistant Enterobacteriaceae in children

Kathleen Chiotos; Pranita D. Tamma; Kelly B. Flett; Manjiree V. Karandikar; Koorosh Nemati; Warren B. Bilker; Theoklis Zaoutis; Jennifer H. Han

doi:10.1093/ofid/ofy222

Increased 30-day mortality associated with carbapenem-resistant Enterobacteriaceae in children

Kathleen Chiotos, Pranita D. Tamma, Kelly B. Flett, Manjiree V. Karandikar, Koorosh Nemati, Warren B. Bilker, Theoklis Zaoutis, Jennifer H. Han

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofy222
State	Published - Oct 1 2018

Keywords

Gram-negative resistance
Klebsiella pneumoniae carbapenemase
Multidrug-resistant organism
Pediatrics

ASJC Scopus subject areas

Infectious Diseases
Oncology

Access to Document

10.1093/ofid/ofy222

Cite this

@article{67e8ee70073940a7b8951de717aad01e,

title = "Increased 30-day mortality associated with carbapenem-resistant Enterobacteriaceae in children",

abstract = "In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.",

keywords = "Gram-negative resistance, Klebsiella pneumoniae carbapenemase, Multidrug-resistant organism, Pediatrics",

author = "Kathleen Chiotos and Tamma, {Pranita D.} and Flett, {Kelly B.} and Karandikar, {Manjiree V.} and Koorosh Nemati and Bilker, {Warren B.} and Theoklis Zaoutis and Han, {Jennifer H.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2018",

month = oct,

day = "1",

doi = "10.1093/ofid/ofy222",

language = "English (US)",

volume = "5",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Increased 30-day mortality associated with carbapenem-resistant Enterobacteriaceae in children

AU - Chiotos, Kathleen

AU - Tamma, Pranita D.

AU - Flett, Kelly B.

AU - Karandikar, Manjiree V.

AU - Nemati, Koorosh

AU - Bilker, Warren B.

AU - Zaoutis, Theoklis

AU - Han, Jennifer H.

N1 - Publisher Copyright: © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

AB - In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

KW - Gram-negative resistance

KW - Klebsiella pneumoniae carbapenemase

KW - Multidrug-resistant organism

KW - Pediatrics

UR - http://www.scopus.com/inward/record.url?scp=85065287531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065287531&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofy222

DO - 10.1093/ofid/ofy222

M3 - Article

C2 - 30338267

AN - SCOPUS:85065287531

SN - 2328-8957

VL - 5

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 10

ER -

Increased 30-day mortality associated with carbapenem-resistant Enterobacteriaceae in children

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this