Increased 2′,5′-oligoadenylate synthetase activity in blood mononuclear leukocytes from patients with advanced cutaneous T-cell lymphoma

Eric C. Vonderheid, Robert J. Suhadolnik, Eugene L. Sobel, Maryann B. Flick, Joseph D. Mosca

Research output: Contribution to journalArticlepeer-review

Abstract

The activity of the interferon-induced enzyme 2′,5′-oligoadenylate synthetase (2′,5′ An synthetase) was found to be increased in the lysates of peripheral blood mononuclear leukocytes obtained from 10 of 25 (40%) patients with cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome). A positive association was found between the level of mean total synthetase activity and extent of involvement (stage) of disease. However, the leukocytes from two patients with relatively high proportions of neoplastic T-cells in the blood (Sézary syndrome) had negligible enzyme activity. It is speculated that increased interferon production in vivo may account for the observed enzyme changes in normal blood leukocytes from these patients, and that the neoplastic T-cell population is the most likely source of the presumed interferon production. Possible mechanisms and biologic consequences of high levels of endogenous interferon in patients with cutaneous T-cell lymphoma are discussed.

Original languageEnglish (US)
Pages (from-to)138-150
Number of pages13
JournalClinical Immunology and Immunopathology
Volume31
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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