Increase of hla-dr4 in melanoma patients from

Bruce O. Barger, Ronald T. Acton, Seng Jaw Soong, Jeffrey Roseman, Charles Balch

Research output: Contribution to journalArticlepeer-review

Abstract

This report describes the association of HLA-DR phenotypes in a population of 91 Caucasian melanoma patients compared with 106 Caucasian controls from the Sunbelt region of the United States. Over 75% of both patients and controls were born in Alabama or a surrounding state. There was a significant increase in the frequency of HLA-DR4 (x2 = 12.8; p = 0.0003). This was present in 38.5% of the patients compared to a 16.0% frequency in the controls, producing a relative risk of 3.3. The difference in DR4 distribution remained significant after correcting for the number of antigens (pc = 0.0018). The patients were then grouped into two categories, “low risk” and “high risk,” based on their clinically assessed risk at presentation for metastatic involvement. The decrease of DR3 in the high-risk group (x2 = 5.2; p = 0.02) suggested that it may represent a marker for long-term survival. Thus, it appears that susceptibility to developing melanoma may be associated with DR4 while survival may be associated with DR3.

Original languageEnglish (US)
Pages (from-to)4276-4279
Number of pages4
JournalCancer Research
Volume42
Issue number10
StatePublished - Oct 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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