Increase in the non-HIV-related deaths among aids cases in the HAART era

Ana M. Novoa, Patricia G. de Olalla, Roser Clos, Angels Orcau, Maica Rodríguez-Sanz, Joan A. Caylà

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective: To analyze the factors associated with survival and to describe the specific causes of death in a large cohort of individuals with Acquired Immune Deficiency 5yndrome (AIDS) in the Highly Active Antiretroviral Therapy (HAART) era. Methods: Subjects over 13 years old recorded in the AID5 registry of Barcelona and diagnosed between 1997-2005 were included. Survival analysis was performed. Causes of death were classified as being HIV-related or non-HIV-related. Results: A total of 1,759 cases were analyzed, 640 (36.3%) of them died during the follow-up. The cumulative probability of survival at five years was of 64% (95% C.I. 62%-67%). The cause of death was non-HIV-related in 28.9% of the cases, among which the most frequent were cancers (20.8%) and liver diseases (18.8%). Conclusion: An increase in the proportion of non-HIV-related deaths has been observed compared to that in the pre-HAART era. The case management of HIV-infected people must be re-directed to influence the risk factors associated with these increasing causes of death.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalCurrent HIV research
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • AIDS
  • Cause of death
  • Epidemiology
  • Risk factors
  • Survival

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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