Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India

Padma Srikanth, Renan Carlos Castillo, Gopalan Sridharan, T. Jacob John, Anand Zachariah, Dilip Mathai, David H. Schwartz

Research output: Contribution to journalArticle

Abstract

Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS. Serum IL-10 levels were significantly higher after 6 months of follow up (P = 0.01), while CD4 counts declined at a rate of 280 cells/ul per year, roughly 3 times the rate of decline reported for HIV+ asymptomatic subjects in developed countries. Changes in serum IL-10 levels and CD4 counts fell short of statistically significant correlation (P = 0.1). Among AIDS patients in this cohort, the mean period from diagnosis of AIDS to death was <5 months and is in agreement with an earlier report of rapid progression in India.

Original languageEnglish (US)
Pages (from-to)49-51
Number of pages3
JournalInternational Journal of STD and AIDS
Volume11
Issue number1
DOIs
StatePublished - 2000

Fingerprint

Interleukin-10
India
Acquired Immunodeficiency Syndrome
CD4 Lymphocyte Count
HIV
T-Lymphocytes
Serum
Developed Countries
Developing Countries
Cytokines

Keywords

  • CD4 counts
  • HIV-1
  • IL-10
  • India
  • Th2

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Immunology

Cite this

Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India. / Srikanth, Padma; Castillo, Renan Carlos; Sridharan, Gopalan; John, T. Jacob; Zachariah, Anand; Mathai, Dilip; Schwartz, David H.

In: International Journal of STD and AIDS, Vol. 11, No. 1, 2000, p. 49-51.

Research output: Contribution to journalArticle

Srikanth, Padma ; Castillo, Renan Carlos ; Sridharan, Gopalan ; John, T. Jacob ; Zachariah, Anand ; Mathai, Dilip ; Schwartz, David H. / Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India. In: International Journal of STD and AIDS. 2000 ; Vol. 11, No. 1. pp. 49-51.
@article{9f0bf4b0c6454084b2819328b460dc83,
title = "Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India",
abstract = "Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS. Serum IL-10 levels were significantly higher after 6 months of follow up (P = 0.01), while CD4 counts declined at a rate of 280 cells/ul per year, roughly 3 times the rate of decline reported for HIV+ asymptomatic subjects in developed countries. Changes in serum IL-10 levels and CD4 counts fell short of statistically significant correlation (P = 0.1). Among AIDS patients in this cohort, the mean period from diagnosis of AIDS to death was <5 months and is in agreement with an earlier report of rapid progression in India.",
keywords = "CD4 counts, HIV-1, IL-10, India, Th2",
author = "Padma Srikanth and Castillo, {Renan Carlos} and Gopalan Sridharan and John, {T. Jacob} and Anand Zachariah and Dilip Mathai and Schwartz, {David H.}",
year = "2000",
doi = "10.1258/0956462001914904",
language = "English (US)",
volume = "11",
pages = "49--51",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India

AU - Srikanth, Padma

AU - Castillo, Renan Carlos

AU - Sridharan, Gopalan

AU - John, T. Jacob

AU - Zachariah, Anand

AU - Mathai, Dilip

AU - Schwartz, David H.

PY - 2000

Y1 - 2000

N2 - Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS. Serum IL-10 levels were significantly higher after 6 months of follow up (P = 0.01), while CD4 counts declined at a rate of 280 cells/ul per year, roughly 3 times the rate of decline reported for HIV+ asymptomatic subjects in developed countries. Changes in serum IL-10 levels and CD4 counts fell short of statistically significant correlation (P = 0.1). Among AIDS patients in this cohort, the mean period from diagnosis of AIDS to death was <5 months and is in agreement with an earlier report of rapid progression in India.

AB - Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS. Serum IL-10 levels were significantly higher after 6 months of follow up (P = 0.01), while CD4 counts declined at a rate of 280 cells/ul per year, roughly 3 times the rate of decline reported for HIV+ asymptomatic subjects in developed countries. Changes in serum IL-10 levels and CD4 counts fell short of statistically significant correlation (P = 0.1). Among AIDS patients in this cohort, the mean period from diagnosis of AIDS to death was <5 months and is in agreement with an earlier report of rapid progression in India.

KW - CD4 counts

KW - HIV-1

KW - IL-10

KW - India

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=0033977835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033977835&partnerID=8YFLogxK

U2 - 10.1258/0956462001914904

DO - 10.1258/0956462001914904

M3 - Article

C2 - 10667901

AN - SCOPUS:0033977835

VL - 11

SP - 49

EP - 51

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 1

ER -