Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India

Padma Srikanth, Renan C. Castillo, Gopalan Sridharan, T. Jacob John, Anand Zachariah, Dilip Mathai, David H. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS. Serum IL-10 levels were significantly higher after 6 months of follow up (P = 0.01), while CD4 counts declined at a rate of 280 cells/ul per year, roughly 3 times the rate of decline reported for HIV+ asymptomatic subjects in developed countries. Changes in serum IL-10 levels and CD4 counts fell short of statistically significant correlation (P = 0.1). Among AIDS patients in this cohort, the mean period from diagnosis of AIDS to death was < 5 months and is in agreement with an earlier report of rapid progression in India.

Original languageEnglish (US)
Pages (from-to)49-51
Number of pages3
JournalInternational Journal of STD and AIDS
Volume11
Issue number1
DOIs
StatePublished - Jan 31 2000

Keywords

  • CD4 counts
  • HIV-1
  • IL-10
  • India
  • Th2

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

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