TY - JOUR
T1 - Increase and plateau of CD4 T-cell counts in the 3 1/2 years after initiation of potent antiretroviral therapy
AU - Tarwater, Patrick M.
AU - Margolick, Joseph B.
AU - Jin, Jianhua
AU - Phair, John P.
AU - Detels, Roger
AU - Rinaldo, Charles
AU - Giorgi, Janis
AU - Muñoz, Alvaro
PY - 2001/6/1
Y1 - 2001/6/1
N2 - We evaluated CD4 cell counts over a 3 1/2 year period following the initiation of potent antiretroviral therapy (ART) in the Multicenter AIDS Cohort Study. The study population included 314 HIV-infected gay men who provided CD4 cell counts for at least 2 years after the initiation of potent ART. Trends in CD4 cell counts and plasma HIV-RNA were analyzed by regression methods that incorporated the statistical dependencies of outcomes measured over time within individuals. Regardless of CD4 cell count at initiation of potent ART, CD4 cell counts increased significantly (p < .05) in the first 2 years after initiation. However, between 2 and 3 1/2 years after initiation, these counts neither increased nor decreased. The pattern of the proportion with plasma HIV-RNA <400 copies/ml was similar to CD4 cell count (i.e., increased significantly after initiation and plateau in the subsequent 1 1/2 years). The single most important predictor of the steady state CD4 cell count that was maintained between 2 and 3 1/2 years after initiation was the change in plasma HIV-RNA in the first year after initiation of potent ART.
AB - We evaluated CD4 cell counts over a 3 1/2 year period following the initiation of potent antiretroviral therapy (ART) in the Multicenter AIDS Cohort Study. The study population included 314 HIV-infected gay men who provided CD4 cell counts for at least 2 years after the initiation of potent ART. Trends in CD4 cell counts and plasma HIV-RNA were analyzed by regression methods that incorporated the statistical dependencies of outcomes measured over time within individuals. Regardless of CD4 cell count at initiation of potent ART, CD4 cell counts increased significantly (p < .05) in the first 2 years after initiation. However, between 2 and 3 1/2 years after initiation, these counts neither increased nor decreased. The pattern of the proportion with plasma HIV-RNA <400 copies/ml was similar to CD4 cell count (i.e., increased significantly after initiation and plateau in the subsequent 1 1/2 years). The single most important predictor of the steady state CD4 cell count that was maintained between 2 and 3 1/2 years after initiation was the change in plasma HIV-RNA in the first year after initiation of potent ART.
KW - CD4 cells
KW - Epidemiologic methods
KW - Longitudinal studies
KW - Potent ART
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U2 - 10.1097/00126334-200106010-00012
DO - 10.1097/00126334-200106010-00012
M3 - Article
C2 - 11404539
AN - SCOPUS:0035362495
SN - 1525-4135
VL - 27
SP - 168
EP - 175
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -