Incorporating first trimester analytes to predict delivery of a large for gestational infant in women with impaired glucose tolerance

Rinat Gabbay-Benziv, Sertac Esin, Ahmet A. Baschat

Research output: Contribution to journalArticle

Abstract

Aim: To investigate first trimester maternal characteristics of women with impaired glucose tolerance that deliver large for gestational age (LGA) infants. Methods: Nested analysis from a prospective study of singleton pregnancies enrolled at first trimester. We studied women with an abnormal 1 h glucose challenge test that had normal follow-up oral glucose tolerance testing. Maternal characteristics, ultrasound parameters and serum analytes were stratified by subsequent delivery of an LGA infant. Parameters identified as significant on univariate analysis were used for a derivation of prediction by logistic regression. Odds ratio and prediction performance was determined using receiver operator curve (ROC) statistics. Results: A total of 33/114 (28.9%) women meeting the criteria delivered LGA infants. Maternal height (cm), and first trimester pregnancy-associated protein-A and free β-hCG (MoM) predicted delivery of an LGA infant (ROC area under curve 0.73; 95% CI 0.63-0.83). At a cutoff value of 0.172 the prediction rule achieved 91% sensitivity, 44% specificity, 41% positive predictive and 92% negative predictive value. Conclusion: Maternal height and first trimester high free β-hCG and PAPP-A levels may be used as predictors for delivery of LGA infants in women with impaired glucose tolerance.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalJournal of Perinatal Medicine
Volume43
Issue number3
DOIs
StatePublished - May 1 2015
Externally publishedYes

Keywords

  • Abnormal glucose challenge test
  • Gestational diabetes
  • Impaired glucose tolerance large for gestational age

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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