Incompatible kidney transplantation: Lessons from a decade of desensitization and paired kidney exchange

Daniel Warren, Robert A. Montgomery

Research output: Contribution to journalArticle


Human leukocyte antigen (HLA) sensitization and ABO incompatibility continue to pose significant barriers to further expansion of live donor renal transplantation. However, the recent development of effective desensitization protocols and creative paired donation strategies demonstrates that the presence of circulating donor HLA-specific antibodies and the use of ABO incompatible organs should no longer be considered contraindications for renal transplantation. It is estimated that as many as 6,000 patients on the kidney transplant waiting list have incompatible living donors and could benefit from these treatments. Furthermore, as our understanding of these treatment modalities has improved, it is now possible to predict whether desensitization, kidney paired donation or a combination of both will provide an individual patient with their best chance for successful renal transplantation.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalImmunologic Research
Issue number1-3
Publication statusPublished - Jul 2010



  • ABO incompatible
  • Intravenous immunoglobulin
  • IVIG
  • Kidney
  • Kidney paired donation
  • Plasmapheresis
  • Positive crossmatch
  • Transplantation

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this