Incidental thyroid nodules and thyroid cancer: Considerations before determining management

Ralph P. Tufano, Salem I. Noureldine, Peter Angelos

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The worldwide incidence of thyroid cancer is increasing substantially, almost exclusively attributable to small papillary thyroid cancers. Increased use of diagnostic imaging is considered the most likely explanation for this reported rise, but other factors may also be contributing. The increase in health care expenditures related to managing these presumably low-risk cancers, without a clear patient benefit, has resulted in a backlash against the early detection of thyroid cancer. Currently, there is no way to confidently predict which incidentally detected thyroid nodule may be the precursor to a more aggressive process. Predictions such as these would require more accurate characterization of the biology of individual thyroid cancers than is currentlypossible.With time, we might prove our ability to confidentlydifferentiate low-risk from high-risk thyroid cancers, but until that happens, routine screening for thyroid cancer by imaging billed as a "health checkup" should not be performed. However, incidentally detected thyroid nodules should be reported, and a clear medical team management plan should be developed. Ourethical responsibility is to providepatientswith objective,evidence-basedinformation about theirdisease status,not to assume that we know what is best for them by selectively withholding information. In addition, providing patients with psychosocial assistance will help them process the information necessary to make informed decisions that will provide them with the most value when a small thyroid nodule or cancer is incidentally identified. Herein, we summarize the epidemiological data for disease incidence, discuss some controversies in disease management, and outline the key elements and ethical considerations of informed decision making as they apply to managing incidentally detected thyroid nodules and thyroid cancer.

Original languageEnglish (US)
Pages (from-to)566-572
Number of pages7
JournalJAMA Otolaryngology - Head and Neck Surgery
Issue number6
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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