Incidental rolandic spikes: Long-term outcomes and impact of treatment

Melanie A. McNally, Eric H. Kossoff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We describe a group of 26 children with no prior history of seizures consistent with benign rolandic epilepsy who had rolandic spikes found coincidentally on EEG. A retrospective chart review as well as phone and email follow-ups with families were completed to assess long-term outcomes. A subset of this group (n. =. 7) with reported comorbid language or learning difficulties was then given an empiric trial of levetiracetam. Seven (27%) children eventually developed seizures, with a median of 14. months after the abnormal EEG. Of the 7 children ever treated with levetiracetam, 5 exhibited beneficial effects on learning, speech, or behavior. Side effects reported were mild and included irritability and headache. Incidental rolandic spikes may represent a discrete neurologic condition, with approximately one-quarter of the patients later developing epilepsy. Some of these children may experience improved intellectual functioning with levetiracetam.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalEpilepsy and Behavior
StatePublished - Feb 1 2015


  • Cognition
  • EEG
  • Epilepsy
  • Levetiracetam
  • Rolandic

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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