Incident Hepatitis C Virus in Women with Human Immunodeficiency Virus Infection

M. Augenbraun, J. J. Goedert, D. Thomas, J. Feldman, E. C. Seaberg, A. L. French, E. Robison, M. Nowicki, N. Terrault

Research output: Contribution to journalArticlepeer-review


Individuals infected with human immunodeficiency virus type 1 (HIV-1) are frequently coinfected with hepatitis C virus (HCV). Acute HCV infection is often asymptomatic and poorly understood. We conducted a historical prospective study of HCV antibody and viremia in plasma samples obtained during 1994-1999 from a cohort of initially HIV-1-infected, HCV-uninfected women and from HIV-1-HCV-uninfected women. Twenty-two (1.5%) of 1517 experienced seroconversion. Of these, 14 (64%) truly acquired a new infection as assessed by enzyme immunoassay response and new-onset viremia. The incidence rate in HIV-1-infected women was 2.7 cases per 1000 person-years; it was 3.3 cases per 1000 person-years in HIV-1-seronegative women (relative risk, 1.21; P = .75). Acquisition of HCV was associated with any history of drug use (P < .01). Five of 12 viremic, seroconverting individuals cleared viremia. Incident HCV infection among HIV-1-infected and HIV-1-uninfected women was low. It was linked to drug use and commonly resolved.

Original languageEnglish (US)
Pages (from-to)1357-1364
Number of pages8
JournalClinical Infectious Diseases
Issue number10
StatePublished - Nov 15 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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