Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study

Jan Bressler, David S. Knopman, A. Richey Sharrett, Rebecca F Gottesman, Alan Penman, Patricia P. Chang, Wayne D. Rosamond, Eric Boerwinkle, Thomas H. Mosley

Research output: Contribution to journalArticle

Abstract

Background Cognitive impairment is found in a significant proportion of patients with heart failure (HF). Although cognitive impairment may be a consequence of HF, early signs of cognitive impairment may also indicate subclinical vascular disease, and thus a risk factor for future cardiovascular events. Methods and Results The Atherosclerosis Risk in Communities Study is a prospective cohort study of the development of atherosclerosis. Cox proportional hazards regression was used to examine the association between mean 6-year change in cognitive function and incident HF in 7962 white and 1933 African-American men and women aged 46 to 70 years and free of clinical stroke. Scores were obtained for the Delayed Word Recall Test, the Digit Symbol Substitution Test (DSST), and the Word Fluency Test. There was a significantly increased risk of developing HF during the mean 12.6-year follow-up period after adjustment for age, gender, race, and education for those in the quartile with the greatest decline in DSST scores (hazard ratio [HR] = 1.17, P = .009), and in the quartile with the lowest baseline DSST scores (HR = 1.43, P < .001). Conclusions The results suggest that relatively low performance on a test of information processing speed may serve as an indicator of HF risk in middle age.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalJournal of Cardiac Failure
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Atherosclerosis
Heart Failure
Automatic Data Processing
Vascular Diseases
African Americans
Cognition
Cohort Studies
Stroke
Cognitive Dysfunction
Prospective Studies
Education

Keywords

  • cognition
  • Epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Incident Heart Failure and Cognitive Decline : The Atherosclerosis Risk in Communities Study. / Bressler, Jan; Knopman, David S.; Sharrett, A. Richey; Gottesman, Rebecca F; Penman, Alan; Chang, Patricia P.; Rosamond, Wayne D.; Boerwinkle, Eric; Mosley, Thomas H.

In: Journal of Cardiac Failure, Vol. 23, No. 1, 01.01.2017, p. 47-55.

Research output: Contribution to journalArticle

Bressler, J, Knopman, DS, Sharrett, AR, Gottesman, RF, Penman, A, Chang, PP, Rosamond, WD, Boerwinkle, E & Mosley, TH 2017, 'Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study', Journal of Cardiac Failure, vol. 23, no. 1, pp. 47-55. https://doi.org/10.1016/j.cardfail.2016.11.002
Bressler, Jan ; Knopman, David S. ; Sharrett, A. Richey ; Gottesman, Rebecca F ; Penman, Alan ; Chang, Patricia P. ; Rosamond, Wayne D. ; Boerwinkle, Eric ; Mosley, Thomas H. / Incident Heart Failure and Cognitive Decline : The Atherosclerosis Risk in Communities Study. In: Journal of Cardiac Failure. 2017 ; Vol. 23, No. 1. pp. 47-55.
@article{929ee262aa9745748043c19bbedfa4b4,
title = "Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study",
abstract = "Background Cognitive impairment is found in a significant proportion of patients with heart failure (HF). Although cognitive impairment may be a consequence of HF, early signs of cognitive impairment may also indicate subclinical vascular disease, and thus a risk factor for future cardiovascular events. Methods and Results The Atherosclerosis Risk in Communities Study is a prospective cohort study of the development of atherosclerosis. Cox proportional hazards regression was used to examine the association between mean 6-year change in cognitive function and incident HF in 7962 white and 1933 African-American men and women aged 46 to 70 years and free of clinical stroke. Scores were obtained for the Delayed Word Recall Test, the Digit Symbol Substitution Test (DSST), and the Word Fluency Test. There was a significantly increased risk of developing HF during the mean 12.6-year follow-up period after adjustment for age, gender, race, and education for those in the quartile with the greatest decline in DSST scores (hazard ratio [HR] = 1.17, P = .009), and in the quartile with the lowest baseline DSST scores (HR = 1.43, P < .001). Conclusions The results suggest that relatively low performance on a test of information processing speed may serve as an indicator of HF risk in middle age.",
keywords = "cognition, Epidemiology",
author = "Jan Bressler and Knopman, {David S.} and Sharrett, {A. Richey} and Gottesman, {Rebecca F} and Alan Penman and Chang, {Patricia P.} and Rosamond, {Wayne D.} and Eric Boerwinkle and Mosley, {Thomas H.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.cardfail.2016.11.002",
language = "English (US)",
volume = "23",
pages = "47--55",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - Incident Heart Failure and Cognitive Decline

T2 - The Atherosclerosis Risk in Communities Study

AU - Bressler, Jan

AU - Knopman, David S.

AU - Sharrett, A. Richey

AU - Gottesman, Rebecca F

AU - Penman, Alan

AU - Chang, Patricia P.

AU - Rosamond, Wayne D.

AU - Boerwinkle, Eric

AU - Mosley, Thomas H.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background Cognitive impairment is found in a significant proportion of patients with heart failure (HF). Although cognitive impairment may be a consequence of HF, early signs of cognitive impairment may also indicate subclinical vascular disease, and thus a risk factor for future cardiovascular events. Methods and Results The Atherosclerosis Risk in Communities Study is a prospective cohort study of the development of atherosclerosis. Cox proportional hazards regression was used to examine the association between mean 6-year change in cognitive function and incident HF in 7962 white and 1933 African-American men and women aged 46 to 70 years and free of clinical stroke. Scores were obtained for the Delayed Word Recall Test, the Digit Symbol Substitution Test (DSST), and the Word Fluency Test. There was a significantly increased risk of developing HF during the mean 12.6-year follow-up period after adjustment for age, gender, race, and education for those in the quartile with the greatest decline in DSST scores (hazard ratio [HR] = 1.17, P = .009), and in the quartile with the lowest baseline DSST scores (HR = 1.43, P < .001). Conclusions The results suggest that relatively low performance on a test of information processing speed may serve as an indicator of HF risk in middle age.

AB - Background Cognitive impairment is found in a significant proportion of patients with heart failure (HF). Although cognitive impairment may be a consequence of HF, early signs of cognitive impairment may also indicate subclinical vascular disease, and thus a risk factor for future cardiovascular events. Methods and Results The Atherosclerosis Risk in Communities Study is a prospective cohort study of the development of atherosclerosis. Cox proportional hazards regression was used to examine the association between mean 6-year change in cognitive function and incident HF in 7962 white and 1933 African-American men and women aged 46 to 70 years and free of clinical stroke. Scores were obtained for the Delayed Word Recall Test, the Digit Symbol Substitution Test (DSST), and the Word Fluency Test. There was a significantly increased risk of developing HF during the mean 12.6-year follow-up period after adjustment for age, gender, race, and education for those in the quartile with the greatest decline in DSST scores (hazard ratio [HR] = 1.17, P = .009), and in the quartile with the lowest baseline DSST scores (HR = 1.43, P < .001). Conclusions The results suggest that relatively low performance on a test of information processing speed may serve as an indicator of HF risk in middle age.

KW - cognition

KW - Epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85007518872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007518872&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2016.11.002

DO - 10.1016/j.cardfail.2016.11.002

M3 - Article

C2 - 27864030

AN - SCOPUS:85007518872

VL - 23

SP - 47

EP - 55

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 1

ER -