Incident gout in women and association with obesity in the Atherosclerosis Risk in Communities (ARIC) study

Janet W. Maynard, Mara Ann McAdams Demarco, Alan Baer, Anna Köttgen, Aaron R. Folsom, Josef Coresh, Allan Gelber

Research output: Contribution to journalArticle

Abstract

BACKGROUND: We hypothesized that women with early- and mid-adult life obesity, as well as high mid-adult life waist-to-hip ratios, and high weight gain during adulthood, experience a greater incidence of gout. METHODS: We examined the incidence of gout in the Atherosclerosis Risk in Communities Study, a population-based biracial cohort comprised of individuals aged 45-65 years at baseline (1987-1989). A total of 6263 women without prior history of gout were identified. We examined the association of body mass index (BMI) and obesity at cohort entry and at age 25 years, waist-to-hip ratio, and weight change with gout incidence (1996-1998). RESULTS: Over 9 years of follow-up, 106 women developed gout. The cumulative incidence of gout, by age 70 years, according to BMI category at baseline of 2, was 1.9, 3.6, 7.9, and 11.8%, respectively (P

Original languageEnglish (US)
JournalAmerican Journal of Medicine
Volume125
Issue number7
DOIs
Publication statusPublished - Jul 2012

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Keywords

  • Arthritis
  • Gout
  • Obesity
  • Weight
  • Women

ASJC Scopus subject areas

  • Medicine(all)

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